Gm962 Activators
Adaptor-related protein complex 5, beta 1 subunit (AP5B1) activators are a diverse group of chemical compounds that indirectly promote the functional activity of AP5B1. AP5B1 plays a crucial role in intracellular trafficking and the sorting of transmembrane proteins. Compounds like GTPγS and Aluminum fluoride (AlF3) interact with GTPase domains, which are integral to the function of AP5B1, stabilizing the protein in an active GTP-bound state. This ensures a more robust participation of AP5B1 in vesicular trafficking processes. Similarly, Forskolin raises cAMP levels, leading to activation of PKA, which in turn can phosphorylate and activate proteins that regulate the vesicular trafficking machinery involving AP5B1.
The function of AP5B1 is also modulated by the cellular phosphorylation state, which can be influenced by compounds such as Okadaic acid and Genistein. Okadaic acid inhibits protein phosphatases, resulting in a higher phosphorylation level of proteins, thus potentially enhancing the activity of AP5B1.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a diacylglycerol analogue that activates protein kinase C (PKC), which can phosphorylate proteins within the vesicular trafficking pathway, potentially enhancing the function of AP5B1 as part of the vesicular transport system. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, which can activate calcium-dependent proteins that interact with or modify the activity of AP5B1 in vesicular trafficking. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A disrupts the Golgi apparatus by inhibiting ARF, which can lead to a compensatory upregulation of other ARF family members or their associated complexes, including AP5B1, enhancing its function in vesicular transport. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
NAD+ is a substrate for ADP-ribosylation reactions which can modify proteins involved in vesicular trafficking and signaling pathways, thereby indirectly enhancing the function of AP5B1. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is another calcium ionophore that increases intracellular calcium levels, which may activate calcium-binding proteins that could enhance the function of AP5B1 in vesicular trafficking and sorting. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A, leading to increased phosphorylation levels of proteins; this could indirectly enhance the function of AP5B1 by affecting proteins that regulate vesicular trafficking. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor, which can alter signaling pathways and potentially enhance the function of AP5B1 by affecting the phosphorylation state of proteins involved in vesicular trafficking. | ||||||
Aluminum Fluoride | 7784-18-1 | sc-291881 sc-291881A | 10 g 50 g | $67.00 $250.00 | ||
AlF3 acts as an analog of the phosphate group and can activate GTPases by stabilizing the transition state, which could lead to the enhanced function of AP5B1 through its role in GTPase-dependent vesicular trafficking. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
LiCl inhibits glycogen synthase kinase-3 (GSK-3), which can affect the phosphorylation state of proteins involved in vesicular transport and signaling pathways, potentially enhancing the function of AP5B1. | ||||||