Gm600 Activators
Nuclear GTPase, germinal center associated (Nuggc) activators encompass a range of compounds that directly or indirectly influence the GTPase activity and function of Nuggc. GTP and GTPγS serve as the primary substrates for the GTPase activity of Nuggc; GTP binding is essential for the activation of Nuggc, while GTPγS, due to its resistance to hydrolysis, leads to a sustained activation. AlF4^- acts as a transition state analog, enhancing the activity of Nuggc by stabilizing the GTP-bound conformation.
The activity of Nuggc is also influenced by the cellular context and the availability of other molecules that affect GTPase function. Compounds like Brefeldin A, Farnesyl pyrophosphate, and Geranylgeranyl pyrophosphate impact the protein indirectly by modulating the environment and post-translational modifications of GTPases. Brefeldin A inhibits ARFs, which can lead to an increase in the active GTP-bound form of Nuggc.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Guanosine-5′-Triphosphate, Disodium salt | 86-01-1 | sc-507564 | 1 g | $714.00 | ||
GTP is the primary substrate for nuclear GTPase, germinal center associated (Nuggc), and is essential for its activation. Binding of GTP to Nuggc leads to a conformational change in the protein, enabling it to perform its GTPase activity. | ||||||
Guanosine 5′-O-(3-thiotriphosphate) tetralithium salt | 94825-44-2 | sc-202639 | 10 mg | $465.00 | ||
GTPγS is a non-hydrolyzable analogue of GTP that can bind to Nuggc, leading to its persistent activation due to resistance to enzymatic cleavage. This can enhance the GTPase activity without turnover. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A is an inhibitor of ADP-ribosylation factors (ARFs), which are small GTPases involved in membrane trafficking. Inhibition of ARFs can lead to the accumulation of GTP-bound forms of related GTPases, potentially enhancing the activity of Nuggc. | ||||||
Farnesyl pyrophosphate ammonium salt | 13058-04-3 | sc-200847 sc-200847A | 1 mg 5 mg | $478.00 $1977.00 | ||
Farnesyl pyrophosphate is involved in the prenylation of proteins, a post-translational modification that can affect the localization and function of GTPases. Enhanced prenylation can increase the membrane association of Nuggc, which may enhance its activity. | ||||||
Geranylgeranylpyrophosphate triammonium salt | 6699-20-3 | sc-200849 | 200 µg | $122.00 | ||
Similar to farnesyl pyrophosphate, geranylgeranyl pyrophosphate serves as a substrate for protein geranylgeranylation, potentially increasing membrane localization and activity of GTPase proteins like Nuggc. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride can inhibit GTPase activating proteins (GAPs), which normally stimulate the GTPase activity of G-proteins, leading to their inactivation. Inhibition of GAPs can result in the enhanced activity of GTPases like Nuggc. | ||||||
Mastoparan | 72093-21-1 | sc-200831 | 1 mg | $99.00 | ||
Mastoparan is a wasp venom peptide that can stimulate G-proteins directly, bypassing receptor activation. This can lead to the enhanced activity of related GTPases, including Nuggc. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $137.00 $512.00 | 7 | |
ML141 is a selective inhibitor of Cdc42, a member of the Rho family of GTPases. Inhibition of Cdc42 can disrupt downstream signaling, potentially altering the activity of other GTPases like Nuggc. | ||||||
NSC 23766 | 733767-34-5 | sc-204823 sc-204823A | 10 mg 50 mg | $151.00 $609.00 | 75 | |
NSC23766 inhibits the activation of Rac1, another Rho family GTPase. This can lead to altered signaling and activity of GTPases within the same pathway, including Nuggc. | ||||||
Zoledronic acid, anhydrous | 118072-93-8 | sc-364663 sc-364663A | 25 mg 100 mg | $92.00 $256.00 | 5 | |
Zoledronic acid inhibits farnesyl diphosphate synthase, leading to reduced prenylation of small GTPases. This can indirectly affect the localization and function of GTPases, potentially enhancing Nuggc activity. | ||||||