GM130 Activators

Common GM130 Activators include, but are not limited to Dexamethasone CAS 50-02-2, Retinoic Acid, all trans CAS 302-79-4, Forskolin CAS 66575-29-9, Tunicamycin CAS 11089-65-9 and Thapsigargin CAS 67526-95-8.

GM130 activators are compounds that stimulate the activity or expression of GM130, a protein integral to the Golgi apparatus's structure and function. The Golgi apparatus is an essential cellular organelle involved in the modification, sorting, and packaging of proteins and lipids for transport to various cellular destinations. GM130, specifically, is a Golgi matrix protein that plays a pivotal role in maintaining the structure of the Golgi and in vesicle trafficking, ensuring the proper function of this cellular "processing center."

One of the notable roles of GM130 is its involvement in the tethering of transport vesicles to the Golgi membranes, a critical step that precedes the fusion of vesicles with the Golgi and the subsequent transfer of their cargo. GM130 achieves this by interacting with various proteins, including GRASP65 and p115, ensuring the accurate and efficient delivery of proteins and lipids to their designated Golgi cisternae. Additionally, GM130 is involved in the maintenance of the Golgi's ribbon-like structure, which is crucial for its functional organization and efficient processing capabilities. GM130 activators, by enhancing the activity or expression of GM130, can amplify its roles in vesicle tethering and Golgi structural maintenance, influencing the overall function of the Golgi apparatus. Given the central importance of the Golgi in protein processing and trafficking, understanding the mechanisms and implications of GM130 activation offers profound insights into cellular logistics, protein modification, and the broader context of intracellular transport. This knowledge underscores the intricacies of cellular organization and the coordinated efforts required to maintain cellular function and homeostasis.