GLP-2R Activators
GLP-2R Activators encompass a range of chemical compounds that serve to elevate the functional capabilities of the GLP-2 receptor (GLP-2R), a critical player in the regulation of intestinal growth and function. Forskolin and 8-Br-cAMP, through their action on the cAMP/PKA signaling pathway, robustly promote GLP-2R signaling; these compounds achieve this by boosting intracellular cAMP levels, which in turn activate PKA that can enhance GLP-2R activity. Liraglutide and Teduglutide, as GLP-2 analogs, bind and activate GLP-2R directly, thereby functioning as potent activators that mimic and amplify the receptor's natural signalingresponses. The cGMP pathway, targeted by Uroguanylin and Sildenafil, works in tandem with cAMP to promote a physiological environment conducive to GLP-2R function, while Zinc acetate, although its direct interaction with GLP-2R is not well established, may act as an allosteric modulator, enhancing the receptor's ability to interact with GLP-2.
The metabolic environment within cells is crucial for the optimal functioning of receptors like GLP-2R, and compounds like Nicotinamide and Dexamethasone contribute to this by enhancing the metabolic profile and cellular conditions favorable for GLP-2R signaling. Nicotinamide does this by boosting cellular NAD+ levels, thereby indirectly supporting enhanced GLP-2R activity. Dexamethasone, a corticosteroid, also modulates protein expression patterns that can potentiate GLP-2 signaling pathways. Additionally, Spermine, with its capacity to influence ion channels and cellular signaling, might create an intracellular milieu that indirectly promotes GLP-2R function. Lastly, the acylated form of Ghrelin raises endogenous GLP-2 levels, leading to increased engagement with GLP-2R and thus potentiating the receptor's signaling cascade. Collectively, these GLP-2R activators work through various biochemical mechanisms to bolster the functional activity of GLP-2R, enhancing its role in maintaining and regulating intestinal health and glucose metabolism without necessitating changes in the receptor's expression levels.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, increasing intracellular cAMP levels. Elevated cAMP activates PKA, which can phosphorylate and enhance the functional activity of GLP-2R, leading to increased GLP-2R signaling in gastrointestinal cells. | ||||||
Liraglutide | 204656-20-2 | sc-507404 | 1 mg | $220.00 | ||
Liraglutide is a GLP-2 analog that binds to and activates GLP-2R directly, enhancing its activity and promoting intestinal growth and glucose homeostasis. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc ions can act as allosteric modulators of various receptors. While not directly proven for GLP-2R, zinc may enhance the receptor's configuration for better interaction with its ligand, potentially improving GLP-2-mediated signaling. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Br-cAMP is a cAMP analog that resists degradation and activates PKA. Persistent PKA activation can enhance GLP-2R signaling by increasing its responsiveness to GLP-2, thus potentially improving the receptor's functional outcomes. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
Nicotinamide has been shown to enhance cellular NAD+ levels, which is crucial for cellular metabolism and function. Higher metabolic activity could indirectly enhance GLP-2R signaling by providing a more favorable cellular environment for its activity. | ||||||
Spermine | 71-44-3 | sc-212953A sc-212953 sc-212953B sc-212953C | 1 g 5 g 25 g 100 g | $61.00 $196.00 $277.00 $901.00 | 1 | |
Spermine can modulate the activity of various ion channels and signaling pathways. By altering cellular homeostasis and signaling, spermine could indirectly create conditions that enhance the activity of GLP-2R, although this effect is not directly established. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone can potentiate the effects of GLP-2 in the intestines by modulating the expression of various proteins and enhancing the overall metabolic milieu. This may indirectly result in more robust signaling through GLP-2R. | ||||||
Ghrelin (human) | 258279-04-8 | sc-364689 sc-364689A | 0.5 mg 1 mg | $186.00 $298.00 | 3 | |
Ghrelin, especially in its acylated form, can enhance the secretion of GLP-2. The increased levels of GLP-2 can then engage GLP-2R more effectively, leading to an indirect enhancement of the receptor's signaling cascade in the gut. | ||||||