GLIPR1L3 Activators
Chemical compounds that serve as GLIPR1L3 Activators function through various biochemical and cellular mechanisms to enhance the activity of GLIPR1L3. These compounds do not directly bind or interact with GLIPR1L3, but they exert their effects on different cellular signaling pathways that GLIPR1L3 is known or anticipated to be involved in, particularly those related to apoptosis and cell survival.
For instance, PMA, a known activator of PKC, could lead to the phosphorylation of downstream proteins that are part of the signaling cascade regulating apoptosis, a process in which GLIPR1L3 is implicated. Activation of PKC by PMA could thereby enhance the pro-apoptotic function of GLIPR1L3. Similarly, Ionomycin, by increasing intracellular calcium levels, could activate calcium-dependent proteins and pathways, which may include those regulating apoptosis where GLIPR1L3 is involved, leading to an increase in GLIPR1L3's activity in promoting cell death. Another example includes Forskolin, which by elevating cAMP levels, leads to the activation of PKA. PKA, in turn, can phosphorylate targets involved in apoptotic pathways, potentially enhancing the activity of GLIPR1L3 in these pathways. Thapsigargin disrupts calcium homeostasis, which could also impact the activity of GLIPR1L3 by activating calcium-dependent apoptotic pathways.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a diester of phorbol and is known to activate protein kinase C (PKC). PKC plays a role in the signal transduction pathways of many cellular processes, including those involved in cell survival and apoptosis. Activation of PKC by PMA can lead to the downstream activation of proteins associated with cell death pathways, in which GLIPR1L3 is a participant, thus enhancing GLIPR1L3's functional activity in these processes. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentration. Elevated calcium levels can activate various calcium-dependent proteins and pathways, potentially including those that GLIPR1L3 is part of, thereby indirectly enhancing the activity of GLIPR1L3 within these pathways. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor that leads to an increase in cytosolic calcium levels. This disruption of calcium homeostasis can activate calcium-dependent signaling pathways, which can include pathways regulating apoptosis, potentially enhancing the functional activity of GLIPR1L3. | ||||||
Piceatannol | 10083-24-6 | sc-200610 sc-200610A sc-200610B | 1 mg 5 mg 25 mg | $51.00 $71.00 $199.00 | 11 | |
Piceatannol inhibits the activity of Syk kinase, which is involved in the regulation of various cellular processes, including cell survival. Inhibition of Syk can lead to the activation of downstream apoptotic pathways where GLIPR1L3 may be functionally active, thus enhancing its role in these pathways. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
S1P is a bioactive lipid that binds to S1P receptors and activates downstream signaling pathways involved in cell survival and apoptosis. Interaction with these pathways can lead to the enhancement of GLIPR1L3 activity, as it is associated with these cellular processes. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases PP1 and PP2A, leading to hyperphosphorylation of cellular proteins. This can affect various signaling cascades, including those related to apoptosis, potentially enhancing the functional activity of GLIPR1L3 in these pathways. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is known to activate stress-activated protein kinases (SAPKs/JNKs) involved in cellular stress responses. Activation of these kinases can influence apoptotic pathways, potentially enhancing the functional activity of GLIPR1L3 in response to cellular stress. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a broad-spectrum kinase inhibitor that can induce apoptosis in a variety of cell types. By influencing the kinases that regulate apoptotic pathways, staurosporine can indirectly enhance the functional activity of GLIPR1L3. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is an inhibitor of MEK1/2, which are upstream of ERK in the MAPK pathway. Inhibition of MEK can lead to altered signaling in the MAPK pathway, which could impact cell survival and apoptosis pathways involving GLIPR1L3, thereby enhancing its activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor that blocks the PI3K/AKT pathway, a key regulator of cell survival. Inhibition of this pathway can lead to the activation of pro-apoptotic signals where GLIPR1L3 can be functionally active, potentially enhancing its role in apoptosis. | ||||||