Date published: 2026-6-9

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Thapsigargin (CAS 67526-95-8)

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Alternate Names:
Thapsigargin also known as Octanoic acid; (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-buten-1-yl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]f uran-7-yl ester; (3S,3aR,4S,6S,6AR,7S,8S,9bS)-6-(Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl octanoate Octanoic acid [(3S)-6 -acetoxy-2,3,3a,4,5,6,6a ,7,8,9b -decahydro-3 ,3a -dihydroxy-3,6,9-trimethyl-8 -[[(Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4 -(1-oxobutoxy)azuleno[4,5-b]furan]-7 -yl ester
Application:
Thapsigargin is a cell-permeable sesquiterpene lactone inducer of intracellular stored Ca2+ release
CAS Number:
67526-95-8
Purity:
≥98%
Molecular Weight:
650.75
Molecular Formula:
C34H50O12
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Thapsigargin is a cell-permeable sesquiterpene lactone found in the roots of Thapsia garganica. Thapsigargin is a tumor promoter and induces the release of intracellular stored Ca2+ without hydrolysis of inositolphospholipids via inhibition of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA IC50=30 nM). Inhibition of SERCAs leads to an increase in intracellular calcium, which has been linked to cell activation, release of histamine from mast cells and increased proliferation of certain types of cancers. Thapsigargin may be used to distinguish between discrete intracellular Ca2+ pools. Thapsigargin-induced tumor promotion and down regulation of the EGF receptor is independent of protein kinase C activation.


Thapsigargin (CAS 67526-95-8) References

  1. Identification of intracellular calcium pools. Selective modification by thapsigargin.  |  Bian, JH., et al. 1991. J Biol Chem. 266: 8801-6. PMID: 1827436
  2. Demonstration of two forms of calcium pumps by thapsigargin inhibition and radioimmunoblotting in platelet membrane vesicles.  |  Papp, B., et al. 1991. J Biol Chem. 266: 14593-6. PMID: 1830588
  3. Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.  |  Thastrup, O., et al. 1990. Proc Natl Acad Sci U S A. 87: 2466-70. PMID: 2138778
  4. Raised calcium and oxidative stress cooperatively promote alpha-synuclein aggregate formation.  |  Goodwin, J., et al. 2013. Neurochem Int. 62: 703-11. PMID: 23159813
  5. Phosphorylation at threonine-654 is not required for negative regulation of the epidermal growth factor receptor by non-phorbol tumor promoters.  |  Friedman, BA., et al. 1989. Proc Natl Acad Sci U S A. 86: 812-6. PMID: 2492663
  6. Cellular models to study bipolar disorder: A systematic review.  |  Viswanath, B., et al. 2015. J Affect Disord. 184: 36-50. PMID: 26070045
  7. Thapsigargin, Origin, Chemistry, Structure-Activity Relationships and Prodrug Development.  |  Quynh Doan, NT. and Christensen, SB. 2015. Curr Pharm Des. 21: 5501-17. PMID: 26429715
  8. Activation of calcium entry by the tumor promoter thapsigargin in parotid acinar cells. Evidence that an intracellular calcium pool and not an inositol phosphate regulates calcium fluxes at the plasma membrane.  |  Takemura, H., et al. 1989. J Biol Chem. 264: 12266-71. PMID: 2663854
  9. Role of endoplasmic reticulum stress in drug-induced toxicity.  |  Foufelle, F. and Fromenty, B. 2016. Pharmacol Res Perspect. 4: e00211. PMID: 26977301
  10. Development of Anticancer Agents from Plant-Derived Sesquiterpene Lactones.  |  Ren, Y., et al. 2016. Curr Med Chem. 23: 2397-420. PMID: 27160533
  11. Endoplasmic Reticulum Calcium Regulates Epidermal Barrier Response and Desmosomal Structure.  |  Celli, A., et al. 2016. J Invest Dermatol. 136: 1840-1847. PMID: 27255610
  12. Ca2+ signaling and emesis: Recent progress and new perspectives.  |  Zhong, W., et al. 2017. Auton Neurosci. 202: 18-27. PMID: 27473611
  13. Palytoxin is a non-12-O-tetradecanoylphorbol-13-acetate type tumor promoter in two-stage mouse skin carcinogenesis.  |  Fujiki, H., et al. 1986. Carcinogenesis. 7: 707-10. PMID: 2870823
  14. A novel tumour promoter, thapsigargin, transiently increases cytoplasmic free Ca2+ without generation of inositol phosphates in NG115-401L neuronal cells.  |  Jackson, TR., et al. 1988. Biochem J. 253: 81-6. PMID: 3138987
  15. Thapsigargin, a novel promoter, phosphorylates the epidermal growth factor receptor at threonine 669.  |  Takishima, K., et al. 1988. Biochem Biophys Res Commun. 157: 740-6. PMID: 3202876

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Thapsigargin, 1 mg

sc-24017
1 mg
$136.00

Thapsigargin, 5 mg

sc-24017A
5 mg
$446.00