GLI-2 Activators
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Purmorphamine | 483367-10-8 | sc-202785 sc-202785A | 1 mg 5 mg | $57.00 $184.00 | 18 | |
Directly activates Smoothened (SMO), leading to activation of the downstream Hedgehog signaling and upregulation of GLI-2. | ||||||
20α-Hydroxy Cholesterol | 516-72-3 | sc-209393 | 10 mg | $300.00 | ||
Oxysterols can activate the Hedgehog pathway by binding to SMO, leading to potential GLI-2 activation. | ||||||
Smoothened Agonist, HCl | 364590-63-6 | sc-202814 sc-202814A | 1 mg 5 mg | $210.00 $520.00 | 31 | |
Directly activates SMO, inducing downstream Hedgehog signaling activation and potentially enhancing GLI-2 activity. | ||||||
Vismodegib | 879085-55-9 | sc-396759 sc-396759A | 10 mg 25 mg | $82.00 $158.00 | 1 | |
It's primarily a SMO antagonist, but in certain contexts, there might be a paradoxical activation of the pathway. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $94.00 $208.00 | 19 | |
Although primarily known as a SMO antagonist, it might cause pathway activation under certain conditions. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Elevates cellular cAMP levels, which can influence Hedgehog signaling and possibly GLI-2 activity. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Impacts various signaling pathways, including Hedgehog. It can modulate GLI-2 expression depending on the cellular context. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Inhibits GSK-3β, which in turn can stabilize and activate components of the Hedgehog pathway, potentially leading to increased GLI-2 activity. | ||||||
Palmitic Acid | 57-10-3 | sc-203175 sc-203175A | 25 g 100 g | $114.00 $286.00 | 2 | |
Palmitoylation is essential for Hedgehog protein function, and fatty acids might influence the pathway and GLI-2 activity. | ||||||
Cholesterol | 57-88-5 | sc-202539C sc-202539E sc-202539A sc-202539B sc-202539D sc-202539 | 5 g 5 kg 100 g 250 g 1 kg 25 g | $27.00 $2809.00 $129.00 $210.00 $583.00 $88.00 | 11 | |
Cholesterol modification is crucial for Hedgehog protein activity, and its levels can influence the Hedgehog pathway and thereby GLI-2. | ||||||