GLCE Inhibitors
Chemical inhibitors of GLCE can engage in various mechanisms to impede its function. Suramin, a polysulfonated naphthylurea, might inhibit GLCE by mimicking the structure of its natural substrates, which would block its function in heparan sulfate synthesis. Metal ions such as manganese(II) chloride, copper(II) sulfate, and zinc sulfate can disturb the metal ion balance required for GLCE's activity. Zinc sulfate may alter the enzyme's function by competing with the essential metal ions.
Further, sodium chlorate, as an oxidizing agent, can alter the redox state of cysteine residues within GLCE, potentially oxidizing critical thiol groups and thus impeding the enzyme's catalytic activity. Tunicamycin, which inhibits N-linked glycosylation, could indirectly inhibit GLCE by reducing the availability of properly glycosylated proteins necessary for its function. Sodium metavanadate can inhibit GLCE by mimicking the enzyme's phosphate group and binding to the active site, which would interfere with the enzyme's access to its substrate. Swainsonine, by inhibiting α-mannosidase II, can lead to a buildup of misprocessed glycoproteins, which could indirectly inhibit GLCE by disrupting its glycoprotein substrates or products. β-D-xyloside acts as a primer for glycosaminoglycan chains and competes with the substrates required by GLCE, thereby inhibiting its activity. Lastly, Rhodamine B, by non-specifically binding to the enzyme or its substrates, can lead to the inhibition of GLCE's enzymatic activity.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Suramin sodium | 129-46-4 | sc-507209 sc-507209F sc-507209A sc-507209B sc-507209C sc-507209D sc-507209E | 50 mg 100 mg 250 mg 1 g 10 g 25 g 50 g | $152.00 $214.00 $728.00 $2601.00 $10965.00 $21838.00 $41096.00 | 5 | |
Suramin is a polysulfonated naphthylurea that can inhibit various enzymes by binding to their substrate-binding sites. For GLCE, suramin might inhibit its activity by mimicking the structure of its natural substrates, thus blocking its function in heparan sulfate synthesis. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $46.00 $122.00 $189.00 | 3 | |
Copper(II) sulfate can bind to proteins and enzymes, altering their conformation and function. In the case of GLCE, copper ions may bind to the enzyme and induce a conformational change that results in decreased activity or inhibit its function by competing with essential metal ions. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc sulfate can interfere with the metal ion cofactors required for enzyme activation. As GLCE may require specific metal ions for its activity, introducing zinc ions could inhibit GLCE by altering its metal ion-dependent conformation or function. | ||||||
Sodium chlorate | 7775-09-9 | sc-212938 | 100 g | $59.00 | 1 | |
Sodium chlorate can act as an oxidizing agent, potentially altering the redox state of cysteine residues in enzymes. This can inhibit GLCE by oxidizing critical thiol groups required for its catalytic activity, thus impeding the enzyme's function. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin inhibits N-linked glycosylation by blocking the transfer of N-acetylglucosamine to dolichol phosphate. As GLCE is involved in glycosaminoglycan biosynthesis, the inhibition of glycosylation could indirectly inhibit GLCE by limiting the availability of properly glycosylated proteins necessary for its function. | ||||||
Sodium metavanadate | 13718-26-8 | sc-251034 sc-251034A | 5 g 25 g | $32.00 $84.00 | 3 | |
Sodium metavanadate is an inhibitor of tyrosine phosphatases and can mimic phosphate groups. GLCE's activity could be inhibited by sodium metavanadate through its binding to the active site, where it could interfere with the enzyme's access to its substrate by mimicking its phosphate group. | ||||||
Swainsonine | 72741-87-8 | sc-201362 sc-201362C sc-201362A sc-201362D sc-201362B | 1 mg 2 mg 5 mg 10 mg 25 mg | $138.00 $251.00 $631.00 $815.00 $1832.00 | 6 | |
Swainsonine is an inhibitor of α-mannosidase II, which is involved in glycoprotein synthesis. By inhibiting this enzyme, swainsonine can lead to a buildup of misprocessed glycoproteins, which could indirectly inhibit GLCE by disrupting the enzyme's glycoprotein substrates or products. | ||||||
4-Methylumbelliferyl-β-D-xylopyranoside | 6734-33-4 | sc-220964 sc-220964A | 25 mg 100 mg | $71.00 $233.00 | ||
β-D-xyloside can act as a primer for glycosaminoglycan chains, diverting substrates away from GLCE and inhibiting its natural activity by competing for the substrates required by GLCE to synthesize heparan sulfate chains. | ||||||