GK2 Inhibitors
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent, non-selective inhibitor of protein kinases. GK2, being a kinase, could be inhibited as staurosporine exhibits broad-spectrum inhibition across the kinase family, potentially obstructing the ATP binding site of GK2, thus preventing its kinase activity. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
Bisindolylmaleimide I specifically inhibits Protein Kinase C (PKC). Since PKC is involved in multiple signaling pathways and could be upstream of GK2, its inhibition can lead to decreased activation of GK2 due to reduced phosphorylation events that are necessary for GK2's function. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a selective inhibitor of c-Jun N-terminal kinase (JNK). By inhibiting JNK, the chemical could reduce the phosphorylation and activation of transcription factors that may be necessary for GK2's function within certain signaling pathways. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a specific inhibitor of PI3K, which is upstream of many kinases. Inhibition of PI3K leads to reduced Akt signaling, which could be essential for GK2's activation or stabilization within the cell. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 inhibits MEK1/2, which is part of the MAPK/ERK pathway. As this pathway is involved in various cellular functions including kinase regulation, the inhibition of MEK1/2 could impede the activation or function of GK2 through reduced phosphorylation signaling. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 selectively inhibits p38 MAP kinase. The p38 pathway is implicated in stress responses, and its inhibition could impair the functional state of GK2 if GK2 is dependent on p38-mediated signaling for its activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a specific and covalent inhibitor of PI3K. By inhibiting PI3K, it decreases the phosphorylation levels of downstream proteins, which could lead to a functional inhibition of GK2 if it relies on PI3K-mediated signaling for activity. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2 is a selective inhibitor of Src family tyrosine kinases. Src kinases can modulate various signaling pathways, including those regulating kinases. Inhibition of Src could lead to reduced activation of GK2, if GK2 is regulated by Src-mediated phosphorylation. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a specific inhibitor of MEK, which acts upstream of ERK in the MAPK pathway. Inhibition of this pathway could decrease ERK-mediated phosphorylation events that may be necessary for the proper function of GK2. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, which is part of the PI3K/AKT/mTOR signaling pathway. mTOR inhibition can lead to a decrease in protein synthesis and kinase activity, which could functionally inhibit GK2 if it is dependent on mTOR signaling for activity or stability. | ||||||