GFRα-3 Activators
GFRα-3 activators are specialized chemicals that target the Glial cell line-Derived Neurotrophic Factor Family Receptor alpha 3 (GFRα-3). GFRα-3 is a member of the GDNF receptor family, which are glycosylphosphatidylinositol (GPI)-anchored cell surface receptors that, together with RET receptor tyrosine kinase, form a receptor complex for ligands from the GDNF family. GFRα-3 specifically binds artemin, playing a critical role in the development and maintenance of the nervous system, influencing neuron survival, and guiding axon growth.
Direct activators of GFRα-3 may bind to the protein and either mimic the effect of its natural ligand, artemin, or enhance the binding and effectiveness of artemin itself. Such activators could stabilize the GFRα-3/RET complex or increase its affinity for the ligand, thereby amplifying the downstream signaling pathways that promote survival and growth of neurons. For example, they might facilitate the dimerization of the RET receptor in the presence of GFRα-3, which is essential for RET's kinase activity that triggers downstream signaling cascades. Indirect activators could modulate GFRα-3 activity by affecting the expression of the GFRα-3 gene, thereby altering the amount of receptor available on the cell surface. Alternatively, they might influence the post-translational processing of the receptor, such as its GPI-anchor attachment, which is crucial for its localization to the cell membrane. Other indirect mechanisms could involve the modulation of the RET receptor itself or the elements of the intracellular signaling pathways that are activated by the GFRα-3/RET complex.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a known activator of adenylate cyclase, an enzyme that increases levels of cyclic Adenosine Monophosphate (cAMP) in the cell. The increase in cAMP can then activate protein kinase A (PKA), which can phosphorylate certain proteins, potentially enhancing the functional activity of GFRα-3. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine, also known as adrenaline, binds to adrenergic receptors, which can lead to increased cAMP levels in the cell. This can activate PKA, potentially resulting in enhanced GFRα-3 activity. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a β-adrenergic agonist, which also increases cAMP levels and activates PKA, potentially enhancing GFRα-3 activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a nonselective phosphodiesterase inhibitor. By inhibiting phosphodiesterase, it prevents the breakdown of cAMP, potentially increasing PKA activity and enhancing GFRα-3 activity. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective phosphodiesterase-4 inhibitor, which can increase cAMP levels and activate PKA, potentially enhancing GFRα-3 activity. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a selective inhibitor of rho-associated protein kinases (ROCKs). ROCKs are involved in various cellular functions, including cell adhesion and neuronal axon guidance, which could impact on GFRα-3 activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor. PI3K is involved in several signaling pathways that influence cell growth and survival, which could intersect with pathways involving GFRα-3. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a selective JNK inhibitor. JNK is a component of the MAPK pathway, and its inhibition could potentially influence GFRα-3 activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a p38 MAPK inhibitor. Like JNK, p38 is a component of the MAPK pathway, and its inhibition could potentially influence GFRα-3 activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a MEK inhibitor. By inhibiting MEK, it affects the ERK/MAPK pathway, which could intersect with pathways involving GFRα-3. | ||||||