Date published: 2026-5-6

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General Crosslinkers

Santa Cruz Biotechnology now offers a broad range of crosslinkers for use in various applications. Crosslinkers are versatile chemical agents that can form covalent bonds between different molecules, thus linking them together. These compounds are crucial in scientific research for stabilizing the structure of proteins, nucleic acids, and other biomolecules, allowing for more accurate studies of their functions and interactions. By creating crosslinked networks, researchers can investigate the three-dimensional structure of macromolecules, study the dynamics of complex biological systems, and enhance the durability and functionality of biomaterials. In material science, crosslinkers are used to develop polymers with improved mechanical properties, such as increased strength and resistance to solvents and heat. Additionally, they play a vital role in developing and optimizing new materials, adhesives, coatings, and composites. The ability of crosslinkers to create strong, stable bonds has also been utilized in various biochemical techniques, such as immunoprecipitation, chromatography, and mass spectrometry, where they help in isolating and identifying specific molecules from complex mixtures. Santa Cruz Biotechnology provides a wide selection of crosslinkers, each with unique properties tailored for specific research needs, ensuring researchers have the tools necessary for their studies. View detailed information on our available crosslinkers by clicking on the product name.

Items 251 to 260 of 343 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

9-Hydroxy-9-(4-carboxyphenyl)xanthene

191168-41-9sc-284863
sc-284863A
1 g
5 g
$150.00
$568.00
(0)

9-Hydroxy-9-(4-carboxyphenyl)xanthene serves as an effective crosslinker, characterized by its ability to form robust covalent bonds through its reactive hydroxyl and carboxylic acid groups. This compound exhibits strong intermolecular interactions, promoting the formation of three-dimensional networks in polymer matrices. Its unique structural features enable tailored modifications, enhancing mechanical properties and thermal stability in various applications. The compound's reactivity is influenced by its conjugated system, allowing for efficient energy transfer during crosslinking processes.

11-Maleimidoundecanoic Acid Sulfo-N-Succinimidyl Ester

211236-68-9sc-213588
sc-213588A
100 mg
250 mg
$320.00
$540.00
(0)

11-Maleimidoundecanoic Acid Sulfo-N-Succinimidyl Ester is a specialized crosslinker distinguished by its sulfo-N-succinimidyl ester moiety, which enhances reactivity towards amines, facilitating efficient conjugation. The presence of the maleimide group allows for selective interactions with thiols, promoting stable linkages. Its hydrophilic sulfonate group improves solubility in aqueous environments, while the extended carbon chain provides flexibility, optimizing crosslinking dynamics in diverse applications.

Heptaoxatricosanedioic Acid Bis(N-Hydroxysuccinimide) Ester

211746-85-9sc-211585
25 mg
$360.00
(0)

Heptaoxatricosanedioic Acid Bis(N-Hydroxysuccinimide) Ester serves as an effective crosslinker due to its multifunctional nature, enabling robust covalent bonding through its reactive ester groups. The presence of multiple hydroxysuccinimide moieties enhances its ability to form stable amide linkages with nucleophiles, promoting tailored network formation. Its unique chain length and flexibility influence the spatial arrangement of crosslinked structures, optimizing mechanical properties and reaction kinetics in polymer matrices.

3,6,9-Trioxaundecane-1,11-diyl-bismethanethiosulfonate

212262-02-7sc-209728
10 mg
$380.00
(0)

3,6,9-Trioxaundecane-1,11-diyl-bismethanethiosulfonate functions as a versatile crosslinker, characterized by its unique bismethanethiosulfonate moieties that engage in selective thiol-ene reactions. This compound's extended ether framework provides enhanced flexibility, enabling effective spatial arrangement during crosslinking. Its reactivity profile allows for controlled polymer network formation, resulting in tailored mechanical attributes and improved thermal stability in composite materials.

3,6-Dioxaoctane-1,8-diyl Bismethanethiosulfonate

212262-04-9sc-209726
10 mg
$360.00
(0)

3,6-Dioxaoctane-1,8-diyl Bismethanethiosulfonate serves as an effective crosslinker, exhibiting unique reactivity through its bismethanethiosulfonate groups. These groups facilitate the formation of covalent bonds with nucleophilic sites, promoting robust network structures. The compound's flexible ether backbone enhances its solubility and compatibility with various substrates, while its ability to undergo rapid reaction kinetics allows for efficient crosslinking in diverse polymer systems, contributing to improved mechanical properties.

3,6,9,12-Tetraoxatetradecane-1,14-diyl-bis-methanethiosulfonate

212262-08-3sc-209729
10 mg
$396.00
(0)

3,6,9,12-Tetraoxatetradecane-1,14-diyl-bis-methanethiosulfonate serves as an innovative crosslinker, distinguished by its dual methanethiosulfonate groups that facilitate robust thiol-disulfide exchange reactions. The compound's elongated tetraoxatetradecane backbone imparts significant molecular mobility, promoting efficient crosslinking kinetics. This results in enhanced network density and improved resilience, contributing to the development of materials with superior mechanical properties and chemical resistance.

Ramage-Linker

212783-75-0sc-296257
sc-296257A
5 g
25 g
$165.00
$928.00
(0)

Ramage-Linker is a specialized crosslinker distinguished by its unique reactivity profile as an acid halide. It engages in selective interactions with nucleophiles, leading to the formation of durable covalent bonds that enhance structural integrity. The compound exhibits a favorable balance of reactivity and stability, allowing for controlled crosslinking processes. Its physical properties, including high solubility in various organic solvents, facilitate seamless integration into complex chemical systems, promoting diverse applications in material science.

5-(4-Hydroxymethyl-3-methoxyphenoxy)valeric acid

213024-57-8sc-233171
1 g
$93.00
(0)

5-(4-Hydroxymethyl-3-methoxyphenoxy)valeric acid acts as a versatile crosslinker, distinguished by its phenolic structure that promotes extensive hydrogen bonding and hydrophobic interactions. This compound's unique molecular architecture allows for selective reactivity with amines and carboxylic acids, facilitating the formation of intricate polymer networks. Its moderate chain length enhances compatibility with various substrates, enabling fine-tuning of mechanical properties and thermal stability in composite materials.

N-Boc-4-isothiocyanatobutylamine

247035-47-8sc-228681
1 ml
$191.00
(0)

N-Boc-4-isothiocyanatobutylamine serves as a versatile crosslinker, characterized by its ability to form robust thiourea bonds through nucleophilic attack. The isothiocyanate moiety promotes selective reactivity with amines, leading to tailored polymer networks. Its Boc group not only stabilizes the compound during initial reactions but also allows for subsequent modifications. This compound's unique reactivity profile enables fine-tuning of crosslinking density, significantly impacting the material's mechanical resilience and thermal stability.

N-Dihydrocinnamoylaminocaproic Acid, N-Hydroxysuccinimide Ester

334616-48-7sc-219147
10 mg
$300.00
(0)

N-Dihydrocinnamoylaminocaproic Acid, N-Hydroxysuccinimide Ester serves as an effective crosslinker, exhibiting robust reactivity through its N-hydroxysuccinimide moiety, which facilitates amine coupling. This compound promotes the formation of stable covalent bonds, enhancing structural integrity in polymer networks. Its unique ability to engage in selective reactions with primary amines allows for tailored modifications, making it a valuable tool in material science for creating complex architectures.