Gemin6 Inhibitors
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Leptomycin B | 87081-35-4 | sc-358688 sc-358688A sc-358688B | 50 µg 500 µg 2.5 mg | $107.00 $416.00 $1248.00 | 35 | |
Leptomycin B inhibits CRM1/exportin 1, a protein that is essential for the nuclear export of many proteins, including snRNP components. Since Gemin6 is part of the SMN complex involved in snRNP assembly, inhibition of nuclear export could indirectly result in the functional inhibition of Gemin6 by preventing its proper localization and assembly functions within the nucleus. | ||||||
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
Bisphenol A binds to estrogen receptors and can disrupt normal endocrine functions, which include the regulation of nuclear transport and assembly of snRNPs. By altering these pathways, Bisphenol A may lead to a disruption of the SMN complex function, indirectly inhibiting Gemin6. | ||||||
Aurintricarboxylic Acid | 4431-00-9 | sc-3525 sc-3525A sc-3525B sc-3525C | 100 mg 1 g 5 g 10 g | $20.00 $32.00 $48.00 $94.00 | 13 | |
Aurintricarboxylic Acid is a polyaromatic polycarboxylic acid known to inhibit nucleases. Because Gemin6 is part of the SMN complex that is involved in the assembly and maturation of snRNPs, inhibition of RNA processing enzymes could indirectly impair the functionality of Gemin6. | ||||||
Phalloidin | 17466-45-4 | sc-202763 | 1 mg | $234.00 | 33 | |
Phalloidin stabilizes F-actin, and by doing so, it can impair various actin-dependent processes including the trafficking of snRNP particles to which Gemin6 contributes. This could indirectly affect the function of Gemin6 by disrupting its associated processes. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule polymerization. Microtubules are necessary for the proper localization of the SMN complex, and thus, disruption could hinder the functionality of Gemin6 by preventing its correct localization in the cell. | ||||||
Daunorubicin hydrochloride | 23541-50-6 | sc-200921 sc-200921A sc-200921B sc-200921C | 10 mg 50 mg 250 mg 1 g | $105.00 $438.00 $837.00 $1569.00 | 4 | |
Daunorubicin intercalates into DNA and can disrupt RNA synthesis. As Gemin6 is involved in snRNP biogenesis, which is RNA-dependent, this could indirectly inhibit the function of Gemin6 by affecting the availability of snRNA components. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide is a diterpene triepoxide that has been shown to inhibit RNA polymerase II. By inhibiting transcription, snRNA components required for Gemin6 function in the SMN complex would be depleted, indirectly inhibiting the function of Gemin6. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D binds to DNA and inhibits RNA polymerase, disrupting RNA synthesis. This would affect the production of snRNAs and other RNA molecules, indirectly inhibiting Gemin6's role in the SMN complex for snRNP assembly. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
α-Amanitin is a potent inhibitor of RNA polymerase II and III. By inhibiting RNA pol II, it would lead to a reduction in snRNA transcription, which could indirectly inhibit Gemin6 function in snRNP assembly. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A disrupts Golgi apparatus function and could impair the trafficking of proteins, including those of the SMN complex. This could result in indirect inhibition of Gemin6 by disrupting its cellular localization and function. | ||||||