Gcn4 Activators
The chemical class of Gcn4 activators encompasses a diverse range of compounds that indirectly influence the activation of Gcn4 through various cellular stress responses and nutrient signaling pathways. These chemicals, although not directly interacting with Gcn4, modulate key pathways that are crucial for its activation. The common theme among these activators is their ability to create a cellular environment that necessitates the activation of Gcn4, primarily through stress responses or nutrient deprivation signals.
These compounds typically function by inducing stress, such as oxidative stress, endoplasmic reticulum stress, or amino acid deprivation, leading to the activation of the Integrated Stress Response (ISR) pathway. Within this pathway, the Gcn2 kinase plays a pivotal role as it is often activated in response to these stresses. Once activated, Gcn2 enhances the translation of Gcn4, thereby increasing its activity. Additionally, some of these compounds, like rapamycin, directly inhibit nutrient-sensing pathways such as the TOR pathway, mimicking a state of nutrient deprivation that leads to Gcn4 activation.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Inhibits the TOR pathway, leading to activation of Gcn2 kinase and subsequent translation of Gcn4. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Inhibits PIKKs including TOR, mimicking nutrient deprivation and leading to activation of Gcn2 and Gcn4. | ||||||
Sodium (meta)arsenite | 7784-46-5 | sc-250986 sc-250986A | 100 g 1 kg | $108.00 $780.00 | 3 | |
Induces oxidative stress and activates the ISR pathway, which activates Gcn2 kinase and Gcn4. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Inhibits N-linked glycosylation, causing endoplasmic reticulum stress and triggering the ISR pathway, leading to Gcn2 and Gcn4 activation. | ||||||
L-Canavanine | 543-38-4 | sc-364687 sc-364687A | 250 mg 1 g | $228.00 $666.00 | ||
Causes amino acid misincorporation and starvation, activating Gcn2 kinase and inducing Gcn4 activation. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
Oxidative stress inducer that activates the ISR pathway, leading to Gcn2 activation and subsequent Gcn4 induction. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Causes endoplasmic reticulum stress by inhibiting the SERCA pump, activating the ISR pathway, Gcn2, and Gcn4. | ||||||
L-Azetidine-2-carboxylic acid | 2133-34-8 | sc-263441 sc-263441A | 1 g 5 g | $139.00 $421.00 | 1 | |
Disrupts protein folding, leading to cellular stress and activation of Gcn2, which subsequently activates Gcn4. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
A kinase inhibitor that can indirectly affect various signaling pathways, potentially leading to cellular stress and the activation of the ISR pathway, which includes Gcn2-mediated activation of Gcn4. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Disrupts Golgi apparatus function, leading to cellular stress and activation of ISR pathway, which includes the activation of Gcn2 and Gcn4. | ||||||