Date published: 2025-10-19

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GCH-I Antibodies

Santa Cruz Biotechnology features a diverse variety of GCH-I monoclonal antibodies for investigating GTP cyclohydrolase I (GCH-I) in various biological processes. GCH-I Antibodies are validated for multiple applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). GCH-I is a critical enzyme in the biosynthesis of tetrahydrobiopterin, a cofactor essential for the production of neurotransmitters such as dopamine, serotonin, and norepinephrine. Its proper function is vital for maintaining normal neurological function and has implications in various disorders, including phenylketonuria and certain neurodegenerative diseases. Understanding the expression and regulation of GCH-I can provide insights into these conditions and aid in the development of therapeutic strategies. GCH-I monoclonal antibodies enable precise detection and analysis of GCH-I expression patterns across different tissues and experimental conditions. Researchers can explore the molecular mechanisms underlying GCH-I function and regulation with exceptional specificity and reliability. Santa Cruz Biotechnology monoclonal antibodies for GCH-I support cutting-edge research that advances our understanding of neurological disorders and potential therapeutic approaches.

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GCH-I Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

GCH-I Antibody (C-4)

sc-271482mouse IgG3 κ210-238 (h)WB, IP, IF, IHC(P), ELISAm, r, h
9
(1)

GCH-I Antibody (G-8)

sc-376483mouse IgG2a κFL (h)WB, IP, IF, ELISAm, r, h
5
(4)

GCH-I CRISPR Knockout, HDR and Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

GCH-I CRISPR/Cas9 KO Plasmid (h)

sc-402386hGene KnockoutGFP0
(0)

GCH-I HDR Plasmid (h)

sc-402386-HDRhHomology Directed RepairPuromycin0
(0)

GCH-I Double Nickase Plasmid (h)

sc-402386-NIChGene KnockoutPuromycin0
(0)

GCH-I Double Nickase Plasmid (h2)

sc-402386-NIC-2hGene KnockoutPuromycin0
(0)

GCH-I CRISPR/Cas9 KO Plasmid (m)

sc-420509mGene KnockoutGFP0
(0)

GCH-I Double Nickase Plasmid (m)

sc-420509-NICmGene KnockoutPuromycin0
(0)

GCH-I Double Nickase Plasmid (m2)

sc-420509-NIC-2mGene KnockoutPuromycin0
(0)

GCH-I CRISPR Activation Products

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

GCH-I CRISPR Activation Plasmid (h)

sc-402386-ACThGene ActivationPuro, Blast, Hygro0
(0)

GCH-I CRISPR Activation Plasmid (h2)

sc-402386-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

GCH-I Lentiviral Activation Particles (h)

sc-402386-LAChGene ActivationPuro, Blast, Hygro0
(0)

GCH-I Lentiviral Activation Particles (h2)

sc-402386-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

GCH-I CRISPR Activation Plasmid (m)

sc-420509-ACTmGene ActivationPuro, Blast, Hygro0
(0)

GCH-I CRISPR Activation Plasmid (m2)

sc-420509-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

GCH-I Lentiviral Activation Particles (m)

sc-420509-LACmGene ActivationPuro, Blast, Hygro0
(0)

GCH-I Lentiviral Activation Particles (m2)

sc-420509-LAC-2mGene ActivationPuro, Blast, Hygro0
(0)

GCH-I siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

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GCH-I siRNA (h)

sc-60675hGene SilencingN/A
2
(0)

GCH-I shRNA Plasmid (h)

sc-60675-SHhGene SilencingPuromycin
2
(0)

GCH-I shRNA (h) Lentiviral Particles

sc-60675-VhGene SilencingPuromycin
2
(0)

GCH-I siRNA (m)

sc-60676mGene SilencingN/A0
(0)

GCH-I shRNA Plasmid (m)

sc-60676-SHmGene SilencingPuromycin0
(0)

GCH-I shRNA (m) Lentiviral Particles

sc-60676-VmGene SilencingPuromycin0
(0)