Gap 1 Activators
The G1 phase is a critical juncture in the cell cycle, representing a period of growth and preparation for DNA replication. It acts as a gateway to the S phase, with intricate controls and checks to ensure proper DNA replication and cell division. Modulation of the G1 phase can be achieved through a variety of chemical agents that either directly impact the key players of this phase or exert their influence through peripheral pathways. Cycloheximide, by blocking protein synthesis, can play a pivotal role in shaping the dynamics of the G1 phase, showcasing the intertwined relationship between protein synthesis and cell cycle progression. On the other hand, chemicals like thymidine emphasize the intricate timing and sequence of events leading to the Gap 1 phase. By causing synchronization of cells, it provides a window into the oscillations between S phase and G1, elucidating the controls governing this transition.
CDK complexes, central to the G1 phase's control, are targeted by chemicals such as Roscovitine and Palbociclib. Their modulation of CDKs offers an avenue to influence G1 phase characteristics and duration. Similarly, agents like Lovastatin and Mimosine throw light on auxiliary pathways, such as cholesterol synthesis and iron chelation, respectively, which have an indirect yet significant influence on G1 progression. Proteasomal activity, highlighted by Lactacystin's function, underscores the role of protein degradation in cell cycle dynamics, particularly in Gap 1. In essence, these chemicals and their specific roles provide a comprehensive understanding of the myriad processes governing the G1 phase, emphasizing its significance and the multifaceted controls that guide it.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide is an inhibitor of protein synthesis. By blocking protein synthesis, it can elevate cyclin D levels, facilitating the advancement of cells through the G1 phase. | ||||||
Thymidine | 50-89-5 | sc-296542 sc-296542A sc-296542C sc-296542D sc-296542E sc-296542B | 1 g 5 g 100 g 250 g 1 kg 25 g | $48.00 $72.00 $265.00 $449.00 $1724.00 $112.00 | 16 | |
Thymidine is a nucleoside analog and can cause synchronization of cells in early S phase. When released from a thymidine block, cells move from S phase back to G1, influencing Gap 1 dynamics. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole disrupts microtubule assembly, arresting cells in M phase. Post-release, these cells transition to G1, allowing for study or modulation of the Gap 1 phase. | ||||||
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $82.00 $300.00 $1082.00 | 30 | |
Aphidicolin is a DNA polymerase α inhibitor, arresting cells at the boundary of G1/S. This creates a heightened emphasis on the processes and controls governing the transition from Gap 1 into S phase. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $92.00 $260.00 | 42 | |
CDK inhibitor that specifically targets CDK2, a key player in G1/S transition. By modulating CDK2 activity, Roscovitine can influence the length and characteristics of the G1 phase. | ||||||
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $315.00 | ||
Palbociclib inhibits CDK4 and CDK6, both crucial for progression through G1. Through this inhibition, it allows a deeper understanding and modulation of the Gap 1 phase dynamics. | ||||||
Lovastatin | 75330-75-5 | sc-200850 sc-200850A sc-200850B | 5 mg 25 mg 100 mg | $28.00 $88.00 $332.00 | 12 | |
Lovastatin inhibits HMG-CoA reductase, leading to a G1 phase arrest. By influencing cholesterol synthesis pathways, which in turn modulate cell membrane functions, Lovastatin can indirectly affect G1 progression. | ||||||
L-Mimosine | 500-44-7 | sc-201536A sc-201536B sc-201536 sc-201536C | 25 mg 100 mg 500 mg 1 g | $35.00 $86.00 $216.00 $427.00 | 8 | |
Mimosine is an iron chelator causing cells to arrest in late G1 phase. It provides insights into iron's role in cell cycle progression and particularly its influence on the G1 phase. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $165.00 $575.00 | 60 | |
Proteasome inhibitor which can induce cell cycle arrest in G1 phase. By halting protein degradation, Lactacystin showcases the importance of proteasome activity in regulating Gap 1 phase dynamics. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide interferes with DNA topoisomerase II, leading to DNA damage and subsequent cell cycle arrest, predominantly at the G2/M boundary but also influencing G1 regulatory mechanisms. | ||||||