γ-SNAP Inhibitors
γ-SNAP inhibitors primarily function by intervening in vesicle-mediated intracellular trafficking processes, given that γ-SNAP plays a pivotal role in the disassembly of the SNARE complex. One of the most significant compounds in this category is N-Ethylmaleimide (NEM), which directly inhibits NSF. NSF is responsible for the disassembly of SNARE complexes, and inhibiting its activity indirectly affects γ-SNAP's function. Similarly, toxins like Tetanus and Botulinum target the SNARE proteins, decreasing vesicle fusion and indirectly influencing γ-SNAP's activity.
Brefeldin A and Golgicide A serve as other potent inhibitors by disrupting transport between vital intracellular structures. The former interrupts the ER-Golgi transport, while the latter specifically targets the Arf1-GBF1 pathway. Given that γ-SNAP aids in vesicular transport, any interference in this transport can indirectly affect its role. Other compounds like Dynasore and SecinH3 inhibit specific proteins or processes that are crucial for vesicle formation, scission, or trafficking. By affecting these processes, they can impact the broader SNARE complex assembly or disassembly processes where γ-SNAP is involved.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
N-Ethylmaleimide | 128-53-0 | sc-202719A sc-202719 sc-202719B sc-202719C sc-202719D | 1 g 5 g 25 g 100 g 250 g | $22.00 $68.00 $210.00 $780.00 $1880.00 | 19 | |
A compound known to inhibit NSF (N-ethylmaleimide-sensitive factor), which can disrupt the disassembly of the SNARE complex and thus the function of γ-SNAP. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Disrupts transport between the ER and Golgi, potentially impacting γ-SNAP's role in vesicular transport. | ||||||
Golgicide A | 1005036-73-6 | sc-215103 sc-215103A | 5 mg 25 mg | $187.00 $670.00 | 11 | |
Targets the Arf1-Golgi brefeldin A-resistant guanine nucleotide exchange factor, indirectly affecting vesicular trafficking processes associated with γ-SNAP. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
Inhibits dynamin, affecting vesicle scission and indirectly the vesicle trafficking processes associated with γ-SNAP. | ||||||
SecinH3 | 853625-60-2 | sc-203260 | 5 mg | $273.00 | 6 | |
Disrupts cytohesin activity and indirectly influences vesicular trafficking processes where γ-SNAP plays a role. | ||||||
Pitstop 2 | 1419093-54-1 | sc-507418 | 10 mg | $360.00 | ||
Acts as a clathrin inhibitor and can affect vesicular transport processes associated with γ-SNAP. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
Disrupts intracellular transport and can have indirect effects on vesicle trafficking processes involving γ-SNAP. | ||||||