galectin-5 Activators
Galectin-5 is a captivating member of the galectin family, known for its unique carbohydrate recognition domain that enables it to bind specifically to beta-galactoside sugars. This protein is chiefly expressed in epithelial cells and has been found to play a role in a myriad of cellular processes, including cell adhesion, cell proliferation, and apoptosis. Galectin-5 has also been shown to have a significant function in the immune response, particularly in the context of inflammation and infection. Its ability to bind to a variety of pathogens suggests a role in the innate immune system as a pattern recognition receptor, identifying and binding to foreign antigens to signal the presence of an invader. The regulation of galectin-5 expression is complex and can be influenced by a variety of intracellular and extracellular factors, reflecting the protein's involvement in diverse biological processes.
In the pursuit of understanding how the expression of galectin-5 can be influenced, various chemicals have been identified as potential activators. These activators can upregulate galectin-5 expression through distinct mechanisms and pathways. For instance, compounds like retinoic acid and Vitamin D3 are known to act through nuclear hormone receptors, possibly enhancing the transcription of genes including galectin-5 when bound to their respective elements. Other molecules, such as hydrogen peroxide, may stimulate galectin-5 expression as part of a cellular response to oxidative stress. Furthermore, epigenetic modifiers, like 5-Azacytidine and Trichostatin A, can alter the chromatin structure around the galectin-5 gene, potentially making it more accessible for transcription and thus increasing gene expression. These activators, alongside others like resveratrol, curcumin, and sulforaphane, demonstrate the diverse mechanisms through which galectin-5 expression can be upregulated, reflecting the intricate regulation of this protein and its responsiveness to various signaling molecules and environmental conditions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid may upregulate galectin-5 by binding to retinoic acid receptors, potentially triggering a cascade of gene activation involved in cellular differentiation where galectin-5 plays a role. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Cholecalciferol could stimulate the transcription of galectin-5 through its hormonal action on vitamin D receptors in immune cells, enhancing immune defense mechanisms. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
By inhibiting DNA methylation, 5-Azacytidine may lead to the demethylation of the galectin-5 gene promoter, thus inducing its transcription in cells where it is epigenetically silenced. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A, as a histone deacetylase inhibitor, may promote the acetylation of histones near the galectin-5 gene, leading to an open chromatin conformation and subsequent transcriptional activation. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
Exposure to hydrogen peroxide may trigger an antioxidant response that includes the upregulation of galectin-5 as part of the cellular protective mechanism against oxidative damage. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol could elevate galectin-5 expression by activating the SIRT1 pathway, which plays a role in cellular stress responses and longevity, potentially including the expression of proteins involved in cell survival. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin may stimulate the expression of galectin-5 by exerting anti-inflammatory actions that entail the activation of genes encoding proteins with a protective role in inflammation. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
DL-Sulforaphane may enhance galectin-5 expression through the activation of the Nrf2 pathway, which upregulates a battery of detoxification and antioxidant genes in response to oxidative stress. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin Gallate may increase the expression of galectin-5 by interacting with signaling pathways involved in cellular protection and apoptosis, promoting the transcription of genes that facilitate cellular homeostasis. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc pyrithione could stimulate the synthesis of galectin-5 by enhancing the immune function, where galectin-5 may be involved in the defense against microbial pathogens. | ||||||