GAGE2B Inhibitors
GAGE2B inhibitors are a class of chemical compounds that specifically target and inhibit the function of the GAGE2B protein, which is part of the GAGE (GAntigen family E) protein family. This family is characterized by its expression in a variety of cellular contexts, particularly within certain cell lines that exhibit unique regulatory properties. GAGE2B, like other members of the GAGE family, contains distinctive amino acid sequences that enable its interaction with various intracellular pathways, contributing to cellular dynamics. Inhibitors of GAGE2B work by binding to active sites or domains of the GAGE2B protein, disrupting its normal activity within the cell. By doing so, they modulate cellular processes that are governed by the interaction of GAGE2B with other molecular components, potentially influencing the regulation of gene expression, protein synthesis, and intracellular signaling pathways.
These inhibitors are usually designed through rational drug design or high-throughput screening methods, where structural features of GAGE2B are exploited to find molecules capable of binding with high affinity. The chemical structures of GAGE2B inhibitors may vary, but they typically consist of small molecules that are capable of crossing cell membranes to reach their target. Once inside the cell, these molecules interact directly with the GAGE2B protein, resulting in its conformational change or inactivation. Understanding the precise molecular mechanisms of GAGE2B inhibition requires detailed studies of the protein's structure, interaction sites, and the physicochemical properties of the inhibitors. These compounds can also serve as tools in biochemical research, enabling scientists to further dissect the role of GAGE2B in various cellular contexts and its involvement in key regulatory networks.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Methotrexate inhibits dihydrofolate reductase, an enzyme involved in purine synthesis. Since G antigen 2B/2C requires purine for its synthesis, the inhibition of purine synthesis leads to the functional inhibition of G antigen 2B/2C. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide inhibits eukaryotic protein synthesis by interfering with the translocation step in protein synthesis, thus inhibiting the synthesis of G antigen 2B/2C. | ||||||
Emetine | 483-18-1 | sc-470668 sc-470668A sc-470668B sc-470668C | 1 mg 10 mg 50 mg 100 mg | $352.00 $566.00 $1331.00 $2453.00 | ||
Emetine inhibits protein synthesis by blocking the ribosomal movement along mRNA, which prevents the elongation of polypeptide chains, leading to the inhibition of the production of G antigen 2B/2C. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin inhibits peptidyl transferase activity in eukaryotic ribosomes, blocking protein synthesis and consequently inhibiting the synthesis of G antigen 2B/2C. | ||||||
Puromycin dihydrochloride | 58-58-2 | sc-108071 sc-108071B sc-108071C sc-108071A | 25 mg 250 mg 1 g 50 mg | $40.00 $210.00 $816.00 $65.00 | 394 | |
Puromycin causes premature chain termination during protein synthesis by acting as an analog of aminoacyl-tRNA, thus inhibiting the production of G antigen 2B/2C. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
α-Amanitin inhibits RNA polymerase II, which is responsible for mRNA synthesis. Inhibition of mRNA synthesis will prevent the production of G antigen 2B/2C. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D binds to DNA and inhibits RNA synthesis, which is necessary for protein synthesis. This will inhibit the production of G antigen 2B/2C. | ||||||
Triton X-100 | 9002-93-1 | sc-29112 sc-29112A | 100 ml 500 ml | $20.00 $41.00 | 55 | |
Triton X-100 can disrupt cell membranes, leading to cell lysis, and thereby inhibit the production and function of G antigen 2B/2C by causing the breakdown of cellular integrity where the protein functions. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine inhibits the lysosomal degradation of proteins, which can lead to the accumulation of misfolded or nonfunctional proteins and thus inhibit the functional maturation of G antigen 2B/2C. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib inhibits the 26S proteasome, which can prevent the degradation of ubiquitinated proteins, leading to cell cycle arrest and inhibition of the production of proteins including G antigen 2B/2C. | ||||||