GABAA R α 2 Activators
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
CL 218872 | 66548-69-4 | sc-203552 sc-203552A | 10 mg 50 mg | $85.00 $319.00 | ||
CL 218872 is characterized by its selective binding affinity to the GABA_A receptor alpha-2 subunit, which modulates neurotransmitter activity. Its unique molecular architecture allows for specific interactions with receptor sites, influencing allosteric modulation. The compound's distinct conformational flexibility enhances its ability to stabilize receptor-ligand complexes, thereby affecting downstream signaling pathways and contributing to its nuanced pharmacodynamics. | ||||||
GABA | 56-12-2 | sc-203053 sc-203053A sc-203053B sc-203053C | 10 g 25 g 5 kg 10 kg | $64.00 $136.00 $459.00 $765.00 | 2 | |
The natural ligand for GABA(A) receptors, binding of GABA leads to receptor activation, allowing chloride ions to enter the neuron and hyperpolarize it. | ||||||
TB 21007 | 207306-50-1 | sc-204322 sc-204322A | 10 mg 50 mg | $172.00 $729.00 | ||
TB 21007 exhibits a remarkable selectivity for the GABA_A receptor alpha-2 subunit, facilitating intricate molecular interactions that enhance its binding efficacy. Its unique structural features promote specific conformational changes within the receptor, optimizing the modulation of inhibitory neurotransmission. The compound's kinetic profile reveals rapid association and dissociation rates, allowing for dynamic regulation of synaptic activity and influencing neuronal excitability in a nuanced manner. | ||||||
TCS 1205 | 355022-97-8 | sc-358561 sc-358561A | 10 mg 50 mg | $141.00 $619.00 | ||
TCS 1205 demonstrates a distinctive affinity for the GABA_A receptor alpha-2 subunit, characterized by its ability to induce specific allosteric changes that stabilize receptor conformation. This compound engages in unique hydrogen bonding and hydrophobic interactions, enhancing its binding stability. Its reaction kinetics are marked by a swift onset of action, enabling precise modulation of receptor activity, which contributes to a finely tuned balance of inhibitory signaling within neural circuits. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc ions can modulate GABA(A) receptor activity, potentially enhancing inhibition. | ||||||
L-838417 | 286456-42-6 | sc-211693 sc-211693A sc-211693B sc-211693C sc-211693D | 5 mg 10 mg 100 mg 500 mg 1 g | $249.00 $430.00 $3000.00 $13500.00 $19500.00 | ||
L-838417 exhibits a selective binding profile for the GABA_A receptor alpha-2 subunit, facilitating unique conformational shifts that enhance receptor functionality. Its molecular interactions are characterized by a combination of electrostatic and van der Waals forces, promoting a robust affinity. The compound's kinetic properties reveal a rapid association and dissociation rate, allowing for dynamic modulation of synaptic transmission and influencing neural excitability in a nuanced manner. | ||||||
Muscimol | 2763-96-4 | sc-200460 sc-200460A | 5 mg 25 mg | $161.00 $537.00 | 2 | |
Muscimol is a direct GABAA Rα2 activator that acts as a GABA analog. By binding to and activating GABAA receptors, including those containing the α2 subunit, Muscimol enhances chloride ion influx, resulting in hyperpolarization and neuronal inhibition. | ||||||
Terephthalic acid | 100-21-0 | sc-255631 sc-255631A | 25 g 100 g | $20.00 $32.00 | 1 | |
TPA is an indirect GABAA Rα2 activator that influences PKC signaling. By activating protein kinase C (PKC), TPA indirectly modulates GABAA Rα2 subunit function. PKC-mediated phosphorylation events can enhance GABAA receptor activity, including those with the α2 subunit, through various intracellular pathways. | ||||||
Etomidate | 33125-97-2 | sc-203577 | 10 mg | $126.00 | ||
Etomidate is a direct GABAA Rα2 activator that enhances GABAergic neurotransmission. By facilitating GABAA receptor function, including those with the α2 subunit, Etomidate promotes chloride ion influx and hyperpolarization, leading to neuronal inhibition. | ||||||