G6pd2 Activators
G6pd2 Activators comprise a category of chemical compounds that are known or logically analyzed to enhance the functional activity of the G6pd2 protein. These activators function primarily through the Nrf2 pathway, which plays a vital role in the upregulation of antioxidant response elements. Compounds such as Dimethyl fumarate, Curcumin, Sulforaphane, Bardoxolone methyl, Oltipraz, and CDDO-Imidazolide areknown to activate Nrf2 either directly or via secondary mechanisms, resulting in the transcriptional upregulation of G6pd2. The upregulation of G6pd2 is critical as it leads to increased availability of NADPH. NADPH is a crucial cofactor for the reduction of glutathione, one of the primary cellular antioxidants, and is also essential for the maintenance of redox balance and the biosynthetic processes that require reductive power. For instance, Sulforaphane, a compound found in cruciferous vegetables, is a particularly potent activator of Nrf2 and thus, by extension, is capable of enhancing G6pd2 activity.
Other compounds like Quercetin and Resveratrol work through different mechanisms but ultimately converge on the Nrf2 pathway, promoting the expression of G6pd2. Quercetin, a flavonoid present in many fruits and vegetables, activates the PI3K/AKT signaling pathway, which can lead to the activation of Nrf2 and subsequent upregulation of G6pd2. Resveratrol, a polyphenol found in grapes and berries, activates SIRT1, which is known to indirectly activate Nrf2. This activation cascade results in the enhancement of G6pd2 levels, thereby augmenting NADPH production. Antioxidants like Butylated hydroxyanisole and Tert-butylhydroquinone also activate Nrf2, leading to increased G6pd2 expression and thus, enhanced cellular capability to manage oxidative stress. Moreover, compounds such as Zinc protoporphyrin IX and Lipoic acid, though not classically associated with Nrf2 activation, can also contribute to the upregulation of G6pd2 expression through their influence on Nrf2 or related pathways. Zinc protoporphyrin IX, while an inhibitor of heme oxygenase-1, has been shown to upregulate Nrf2, and Lipoic acid is recognized for its capacity to enhance Nrf2 activity, thereby promoting the transcription of genes like G6pd2 involved in maintaining cellular redox homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dimethyl fumarate | 624-49-7 | sc-239774 | 25 g | $27.00 | 6 | |
Dimethyl fumarate activates the Nrf2 pathway. Nrf2 upregulation can lead to increased expression of antioxidant response genes, including G6pd2, which provides cells with NADPH, crucial for maintaining redox balance and enhancing cell survival. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can activate Nrf2 signaling. By upregulating Nrf2, Curcumin enhances the expression of G6pd2, which in turn increases the availability of NADPH for antioxidant defense and reductive biosynthesis, enhancing cellular redox homeostasis. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane is a potent Nrf2 activator. Its activation of Nrf2 leads to the transcriptional upregulation of G6pd2, thereby increasing the production of NADPH to support antioxidant systems and protect against oxidative stress. | ||||||
CDDO Methyl Ester | 218600-53-4 | sc-504720 | 10 mg | $220.00 | ||
Bardoxolone methyl is an Nrf2 activator. By stimulating Nrf2, it promotes the expression of G6pd2, which is pivotal for generating NADPH, crucial for combating oxidative stress and enhancing the reductive capacity of cells. | ||||||
Oltipraz | 64224-21-1 | sc-205777 sc-205777A | 500 mg 1 g | $286.00 $622.00 | ||
Oltipraz is known to induce phase II detoxifying enzymes through Nrf2 activation. By enhancing Nrf2 activity, Oltipraz can increase the expression of G6pd2, which in turn augments the production of NADPH, bolstering antioxidant defenses. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin activates the PI3K/AKT pathway, which can lead to Nrf2 activation. Upon activation, Nrf2 can induce the expression of G6pd2, thereby enhancing the availability of NADPH for cellular defense against oxidative damage. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is known to activate SIRT1, which can indirectly activate Nrf2. Activation of Nrf2 can subsequently upregulate G6pd2 expression, enhancing NADPH production to support antioxidant systems and promote redox homeostasis. | ||||||
CDDO Imidazolide | 443104-02-7 | sc-504719 | 1 mg | $700.00 | ||
CDDO-Imidazolide is a synthetic triterpenoid that activates Nrf2. Activation of Nrf2 leads to increased expression of G6pd2, thus elevating NADPH levels, which are necessary for neutralizing oxidative stress and maintaining cellular homeostasis. | ||||||
Butylated hydroxyanisole | 25013-16-5 | sc-252527 sc-252527A | 5 g 100 g | $29.00 $96.00 | 1 | |
Butylated hydroxyanisole (BHA) is an antioxidant that can induce Nrf2-mediated gene expression. This induction includes upregulation of G6pd2, which enhances the production of NADPH needed for antioxidative responses and reductive reactions. | ||||||
t-Butylhydroquinone | 1948-33-0 | sc-202825 | 10 g | $66.00 | 4 | |
Tert-butylhydroquinone (tBHQ) is an antioxidant that activates Nrf2. By activating Nrf2, tBHQ increases the transcription of G6pd2, which plays a key role in providing NADPH to counteract oxidative stress and support biosynthetic processes. | ||||||