Date published: 2026-4-10

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FSTL4 Inhibitors

FSTL4 inhibitors constitute a class of chemical compounds designed to selectively modulate the activity of Follistatin-like protein 4 (FSTL4), a secreted glycoprotein that is part of the Follistatin family. These inhibitors are developed with the primary aim of studying the biological functions and regulatory mechanisms associated with FSTL4, rather than for any immediate application. FSTL4 itself is known for its diverse roles in various cellular processes, including embryonic development, tissue regeneration, and immune regulation. It is typically found in extracellular matrices and can interact with various growth factors, cytokines, and cell surface receptors, suggesting its involvement in intricate signaling pathways. The development of FSTL4 inhibitors involves the synthesis and optimization of small molecules or biologics that can specifically bind to FSTL4, thus modulating its biological activity. Researchers use these inhibitors as valuable tools in laboratory settings to dissect the intricate functions and interactions of FSTL4 within cellular and molecular contexts
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

SB 431542

301836-41-9sc-204265
sc-204265A
sc-204265B
1 mg
10 mg
25 mg
$82.00
$216.00
$416.00
48
(1)

Inhibits the activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7, which are part of the TGF-β superfamily. This leads to decreased SMAD2/3 phosphorylation and subsequently TGF-β signaling inhibition.

SB-505124

694433-59-5sc-362794
sc-362794A
10 mg
50 mg
$327.00
$1377.00
2
(0)

A selective inhibitor of ALK4 and ALK5, which are TGF-β type I receptors. Reduces SMAD2/3 activation by TGF-β.

4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline

1062368-24-4sc-476297
5 mg
$240.00
(0)

A selective inhibitor of BMP type I receptors ALK2, ALK3, and ALK6, leading to reduced phosphorylation of SMAD1/5/8 and inhibition of the BMP signaling pathway.

ALK5 Inhibitor II

446859-33-2sc-221234
sc-221234A
sc-221234B
sc-221234C
sc-221234D
sc-221234E
sc-221234F
1 mg
5 mg
10 mg
50 mg
100 mg
500 mg
1 g
$77.00
$153.00
$219.00
$663.00
$1248.00
$4382.00
$7850.00
8
(1)

Inhibits the TGF-β type I receptor ALK5, leading to reduced SMAD2/3 activation and TGF-β signaling suppression.

GW788388

452342-67-5sc-363544
sc-363544A
5 mg
25 mg
$95.00
$384.00
(0)

A potent inhibitor of ALK5 and ALK4, leading to suppression of the TGF-β signaling pathway. Reduces SMAD2/3 phosphorylation.

DMH-1

1206711-16-1sc-361171
sc-361171B
sc-361171A
sc-361171C
10 mg
25 mg
50 mg
100 mg
$213.00
$318.00
$632.00
$1047.00
2
(0)

Selective BMP receptor inhibitor, targeting ALK2, ALK3, and ALK6, leading to the suppression of BMP-induced SMAD1/5/8 phosphorylation.

A 83-01

909910-43-6sc-203791
sc-203791A
10 mg
50 mg
$202.00
$811.00
16
(1)

Inhibits ALK4, ALK5, and ALK7, leading to suppression of TGF-β/activin/nodal signaling. It prevents the phosphorylation of SMAD2/3.