FSHα Activators
FSHα activators belong to a chemical class of compounds that possess the unique capability to modulate the activity of Follicle-Stimulating Hormone alpha subunit (FSHα). FSHα is a fundamental component of the pituitary hormone known as FSH, a critical regulator of reproductive processes in both males and females. FSH is composed of two subunits, alpha (α) and beta (β), with FSHα representing the alpha subunit. This hormone plays a pivotal role in the regulation of gonadal function and fertility. Activators of FSHα are molecules that have the ability to enhance or regulate the expression and activity of this alpha subunit, ultimately influencing the overall function of FSH.
The activation of FSHα by these compounds can occur through various mechanisms, such as promoting its gene expression, enhancing its assembly with the beta subunit to form the functional FSH hormone, or facilitating its secretion from the pituitary gland. By modulating FSHα, these activators can have profound effects on reproductive physiology and the maturation of gametes (sperm and eggs). Understanding the regulation of FSHα and the compounds that can activate it is essential for unraveling the intricacies of the reproductive system and its role in ensuring the continuation of species. It offers insights into the control of follicular development, spermatogenesis, and hormonal balance in the context of reproduction.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $116.00 $179.00 $265.00 $369.00 $629.00 $1150.00 | ||
cAMP analogs may bypass cellular receptors and directly stimulate the production of FSH through activation of protein kinase A (PKA). | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin increases intracellular cAMP, which can enhance the synthesis of FSH in the pituitary gland. | ||||||
Ob (hBA-147) | sc-4912 | 1000 µg | $258.00 | 1 | ||
Leptin has been shown to modulate reproductive function and could influence the synthesis of FSH. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
Insulin sensitizers may affect hormonal balance, potentially affecting the regulation of FSH production. | ||||||
GABA | 56-12-2 | sc-203053 sc-203053A sc-203053B sc-203053C | 10 g 25 g 5 kg 10 kg | $64.00 $136.00 $459.00 $765.00 | 2 | |
GABA agonists can have an inhibitory effect on the CNS, which might indirectly affect the secretion of gonadotropins like FSH. | ||||||