frizzled-8 Activators
Frizzled-8 Activators, as a chemical class, refer to a group of compounds that can influence the Wnt signaling pathway either directly or indirectly. Their mode of action on the pathway is varied, with some chemicals directly targeting components of the Wnt pathway, while others operate through upstream or downstream processes. Lithium Chloride, SB216763, BIO, and CHIR99021 are examples of compounds that inhibit GSK-3β, leading to the stabilization of β-catenin and activation of the Wnt signaling pathway.
On the other hand, compounds like XAV939 operate by inhibiting tankyrase, thus promoting the degradation of β-catenin. Another method of influencing the pathway is seen with compounds like Wnt-C59, which affects the secretion of Wnt ligands, thus indirectly modulating the Wnt pathway activity. This broad range of operational methods allows for diverse modulation of the Wnt signaling pathway, highlighting the significance and adaptability of this chemical class in influencing Frizzled-8 and associated cellular processes.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Activates the Wnt pathway by inhibiting glycogen synthase kinase-3β (GSK-3β), which stabilizes β-catenin. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $71.00 $202.00 | 18 | |
GSK-3β inhibitor, leading to β-catenin stabilization and Wnt pathway activation. | ||||||
GSK-3 Inhibitor IX | 667463-62-9 | sc-202634 sc-202634A sc-202634B | 1 mg 10 mg 50 mg | $58.00 $188.00 $884.00 | 10 | |
Known GSK-3 inhibitor, which activates the Wnt/β-catenin signaling pathway. | ||||||
GSK-3 Inhibitor XVI | 252917-06-9 | sc-221691 sc-221691A | 5 mg 25 mg | $180.00 $610.00 | 4 | |
Inhibits GSK-3, resulting in β-catenin accumulation and activation of Wnt signaling. | ||||||