FMNL3 inhibitors, as referred to in this context, encompass a variety of chemical agents that can indirectly affect the activity of FMNL3 by targeting actin dynamics and related signaling pathways. These inhibitors do not bind directly to FMNL3 but can influence the processes in which FMNL3 is involved, such as actin polymerization and organization, which are critical for cellular structure and function. Chemicals like Cytochalasin D, Latrunculin A, and Swinholide A are known to bind directly to actin filaments or monomers, thereby preventing the polymerization and elongation of actin, which are key steps in which FMNL3 is known to participate. Cytochalasin D caps the barbed ends of actin filaments, Latrunculin A sequesters actin monomers, and Swinholide A severs actin filaments. These actions can impede the ability of FMNL3 to promote actin assembly, thereby indirectly inhibiting its function.
Other compounds, such as Jasplakinolide and Chondramide, target actin in different ways; Jasplakinolide stabilizes actin filaments, while Chondramide binds to actin and inhibits its polymerization. These alterations in actin dynamics can disrupt the normal regulatory role of FMNL3 in actin filament formation and stabilization. Additionally, CK-666 and SMIFH2 inhibit the Arp2/3 complex and formin homology 2 (FH2) domain-containing proteins, respectively, both of which are involved in actin nucleation and elongation, processes that FMNL3 regulates. Y-27632, Blebbistatin, ML-7, and Thiazovivin all target the actin-myFMNL3 inhibitors, as referred to in this context, encompass a variety of chemical agents that can indirectly affect the activity of FMNL3 by targeting actin dynamics and related signaling pathways. These inhibitors do not bind directly to FMNL3 but can influence the processes in which FMNL3 is involved, such as actin polymerization and organization, which are critical for cellular structure and function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Binds to the barbed ends of actin filaments, preventing elongation and potentially affecting FMNL3-mediated actin polymerization. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $260.00 $799.00 | 36 | |
Binds to actin monomers and sequesters them, thereby inhibiting actin polymerization that FMNL3 is involved in. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $180.00 $299.00 | 59 | |
Stabilizes actin filaments and prevents their disassembly, which may indirectly affect FMNL3's activity in actin dynamics. | ||||||
Mifepristone | 84371-65-3 | sc-203134 | 100 mg | $60.00 | 17 | |
Binds to actin and inhibits its polymerization, potentially altering the actin assembly process in which FMNL3 is involved. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $315.00 $1020.00 | 5 | |
Inhibits the Arp2/3 complex, which can impact actin nucleation and branching, processes that are modulated by FMNL3. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
ROCK inhibitor, which may lead to changes in actin cytoskeleton dynamics and potentially influence FMNL3-mediated processes. | ||||||
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $71.00 $260.00 $485.00 $949.00 | ||
Inhibits myosin II, which can alter actin-myosin interactions and subsequently affect FMNL3's role in actin organization. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $89.00 $262.00 | 13 | |
Inhibits myosin light chain kinase (MLCK), affecting actin-myosin contraction that can indirectly influence FMNL3 activity. | ||||||
Thiazovivin | 1226056-71-8 | sc-361380 sc-361380A | 10 mg 25 mg | $278.00 $622.00 | 15 | |
Inhibits Rho-associated protein kinase (ROCK), potentially impacting actin cytoskeleton organization and FMNL3 function. | ||||||
GSK2126458 | 1086062-66-9 | sc-364503 sc-364503A | 2 mg 10 mg | $260.00 $1029.00 | ||
Inhibitor of Trk, which may affect neuronal growth and actin dynamics, thereby potentially influencing FMNL3's role in these processes. | ||||||