Date published: 2025-10-9

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FLIPL Inhibitors

FLIPL inhibitors comprise a diverse range of chemical entities designed to modulate cellular processes governed by FLIPL, a critical regulator of apoptosis. FLIPL, a member of the inhibitor of apoptosis (IAP) family, exerts its anti-apoptotic function by inhibiting caspase activation and interfering with apoptotic cascades. Researchers have identified various small molecules that either directly target FLIPL or influence signaling pathways associated with its activity. Curcumin and Embelin, both natural compounds, indirectly inhibit FLIPL by modulating the NF-κB signaling pathway. Curcumin's suppression of NF-κB activation results in decreased FLIPL expression, impacting its role in apoptotic pathways. Embelin, in addition to its NF-κB modulation, also acts as a dual inhibitor by disrupting XIAP-mediated suppression of FLIPL. These indirect inhibitors influence cellular processes governed by FLIPL, contributing to their pharmacological effects. Proteasome inhibitors like Bortezomib indirectly affect FLIPL by modulating the NF-κB signaling pathway. Bortezomib's inhibition of the proteasome prevents the degradation of IκBα, leading to decreased FLIPL expression and subsequent alterations in apoptotic pathways. Natural products, including Betulinic Acid, Gossypol, and Obatoclax, exert their effects on FLIPL through modulation of the NF-κB signaling pathway. These compounds interfere with NF-κB activation, resulting in decreased FLIPL expression and influencing its role in apoptotic pathways. The BH3 mimetic Obatoclax indirectly inhibits FLIPL by interacting with Bcl-2 family proteins, impacting the mitochondrial apoptotic pathway and leading to decreased FLIPL expression. Survivin suppressants, such as YM155, indirectly inhibit FLIPL by modulating survivin levels. The interference with survivin expression influences apoptotic pathways associated with FLIPL, contributing to decreased FLIPL activity.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$36.00
$68.00
$107.00
$214.00
$234.00
$862.00
$1968.00
47
(1)

Curcumin is a natural compound that indirectly inhibits FLIPL by influencing the NF-κB signaling pathway. Its suppression of NF-κB activation leads to decreased FLIPL expression, altering its interaction with other components in apoptotic pathways. This indirect inhibition impacts cellular processes governed by FLIPL, contributing to the pharmacological effects of Curcumin.

Embelin

550-24-3sc-201555
sc-201555A
10 mg
50 mg
$87.00
$332.00
5
(2)

Embelin is a natural product that indirectly inhibits FLIPL by modulating the NF-κB signaling pathway. Its interference with NF-κB activation results in decreased FLIPL expression, influencing its role in apoptotic pathways. This indirect inhibition impacts cellular processes governed by FLIPL, contributing to the pharmacological effects of Embelin.

Bortezomib

179324-69-7sc-217785
sc-217785A
2.5 mg
25 mg
$132.00
$1064.00
115
(2)

Bortezomib is a proteasome inhibitor that indirectly affects FLIPL by modulating the NF-κB signaling pathway. Its inhibition of the proteasome prevents the degradation of IκBα, leading to decreased FLIPL expression. This indirect inhibition impacts cellular processes governed by FLIPL, contributing to the pharmacological effects of Bortezomib.

Betulinic Acid

472-15-1sc-200132
sc-200132A
25 mg
100 mg
$115.00
$337.00
3
(1)

Betulinic Acid is a natural product that indirectly inhibits FLIPL by modulating the NF-κB signaling pathway. Its interference with NF-κB activation results in decreased FLIPL expression, influencing its role in apoptotic pathways. This indirect inhibition impacts cellular processes governed by FLIPL, contributing to the pharmacological effects of Betulinic Acid.

Birinapant

1260251-31-7sc-503590
sc-503590A
1 mg
5 mg
$160.00
$360.00
(0)

Birinapant is a SMAC mimetic that directly inhibits FLIPL by promoting caspase activation. Its interaction with FLIPL prevents its anti-apoptotic function, leading to the initiation of apoptotic cascades. This direct inhibition impacts cellular processes governed by FLIPL, contributing to the pharmacological effects of Birinapant.

Obatoclax Mesylate

803712-79-0sc-364221
sc-364221A
5 mg
10 mg
$94.00
$138.00
(1)

Obatoclax is a BH3 mimetic that indirectly inhibits FLIPL by modulating the Bcl-2 family proteins. Its interaction with Bcl-2 proteins influences the mitochondrial apoptotic pathway, leading to decreased FLIPL expression. This indirect inhibition impacts cellular processes governed by FLIPL, contributing to the pharmacological effects of Obatoclax.

Gossypol

303-45-7sc-200501
sc-200501A
25 mg
100 mg
$114.00
$225.00
12
(1)

Gossypol is a natural product that indirectly inhibits FLIPL by modulating the NF-κB signaling pathway. Its interference with NF-κB activation results in decreased FLIPL expression, influencing its role in apoptotic pathways. This indirect inhibition impacts cellular processes governed by FLIPL, contributing to the pharmacological effects of Gossypol.

YM 155

781661-94-7sc-364661
sc-364661A
5 mg
25 mg
$129.00
$497.00
3
(0)

YM155 is a survivin suppressant that indirectly inhibits FLIPL by modulating survivin levels. Its interference with survivin expression influences the apoptotic pathways associated with FLIPL, leading to decreased FLIPL activity. This indirect inhibition impacts cellular processes governed by FLIPL, contributing to the pharmacological effects of YM155.

Q-VD-OPH

1135695-98-5sc-222230
5 mg
$782.00
5
(1)

Q-VD-OPh is a broad-spectrum caspase inhibitor that directly inhibits FLIPL by preventing caspase activation. Its interaction with caspases prevents their activation, disrupting the apoptotic cascades governed by FLIPL. This direct inhibition impacts cellular processes governed by FLIPL, contributing to the pharmacological effects of Q-VD-OPh.