FIC1 Activators
The modulation of FIC1, a critical phospholipid transporting ATPase, is indirectly influenced by a variety of compounds that affect cellular lipid composition, membrane integrity, and overall hepatic health. Ursodeoxycholic Acid (UDCA) and its taurine-conjugated derivative, Tauroursodeoxycholic Acid (TUDCA), are notable for their capacity to stabilize hepatocyte membranes and improve bile flow, indirectly maintaining the functional milieu necessary for FIC1 activity. Similarly, compounds like Phosphatidylcholine and Choline directly contribute to the optimal composition of bile, supporting FIC1's role in phospholipid transport by ensuring an adequate supply of essential bile components. Supplementation with S-Adenosylmethionine (SAMe) contributes to hepatocyte membrane stability and fluidity, crucial for the proper functioning of transport proteins like FIC1, while antioxidants such as Epigallocatechin Gallate (EGCG) and Vitamin E preserve cellular integrity and function by protecting against oxidative stress, indirectly benefiting FIC1 activity.
Moreover, agents like Curcumin and Miltefosine, known for their hepatoprotective and phospholipid-altering properties respectively, may influence the lipid environment and overall health of liver cells, indirectly affecting FIC1 function. Bezafibrate, by improving lipid metabolism and potentially influencing bile composition, along with Rifampicin, known for its enzyme-inducing effects, might also modulate FIC1 activity indirectly. Lastly, Nicotinamide, through its broad effects on cellular health and metabolism, might affect membrane dynamics or cellular conditions, thereby indirectly modulating the activity of FIC1. Collectively, these compounds, through their targeted effects on hepatic function, lipid metabolism, and cellular health, offer insights into the complex regulation of FIC1, underscoring the indirect yet significant influence that various biochemical and pharmacological agents can exert on this essential phospholipid transporter's activity. These insights are critical for understanding the modulation of FIC1, particularly in the context of liver diseases such as progressive familial intrahepatic cholestasis, where its proper function is crucial for maintaining bile flow and liver health.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ursodeoxycholic acid | 128-13-2 | sc-204935 sc-204935A | 1 g 5 g | $51.00 $128.00 | 4 | |
Ursodeoxycholic Acid (UDCA) is studied in the research of various cholestatic conditions. It can indirectly enhance FIC1 function by stabilizing the hepatocyte membrane, improving bile flow, and reducing the toxic effects of bile acids. Improved bile acid flow and reduced hepatocyte damage might indirectly maintain FIC1 function by preserving the cellular environment in which FIC1 operates. | ||||||
Tauroursodeoxycholic Acid, Sodium Salt | 14605-22-2 | sc-281165 | 1 g | $644.00 | 5 | |
Tauroursodeoxycholic Acid (TUDCA) is a taurine-conjugated bile acid that has been shown to reduce endoplasmic reticulum stress and stabilize cellular membranes. By reducing cellular stress and stabilizing membranes, TUDCA could indirectly support FIC1 function, particularly under conditions of stress or damage that might otherwise impair the protein's activity or expression. | ||||||
L-α-Lecithin, Egg Yolk, Highly Purified | 8002-43-5 | sc-203096 | 250 mg | $78.00 | ||
Phosphatidylcholine is a major component of bile and is essential for its proper formation and secretion. Supplementing with phosphatidylcholine could support overall bile flow and composition, indirectly maintaining FIC1 activity by ensuring optimal conditions for its function in phospholipid transport. | ||||||
Choline chloride | 67-48-1 | sc-207430 sc-207430A sc-207430B | 10 mg 5 g 50 g | $32.00 $36.00 $51.00 | 1 | |
Choline is a precursor for phosphatidylcholine and is essential for liver function. By supporting the synthesis of phosphatidylcholine, choline supplementation could indirectly enhance FIC1 function by improving the quality and flow of bile, where FIC1 is actively involved in phospholipid transport. | ||||||
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $180.00 $655.00 | 2 | |
SAMe is involved in methylation processes and is studied in the research of various liver diseases. It can indirectly support FIC1 function by contributing to the maintenance of hepatocyte membrane stability and fluidity, which are crucial for the proper functioning of transport proteins like FIC1. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin Gallate (EGCG) from green tea has various hepatoprotective effects, including antioxidant properties. While not directly targeting FIC1, EGCG could support liver health and cellular membranes, indirectly benefiting FIC1 function by maintaining a healthy cellular environment for its operation. | ||||||
(+)-α-Tocopherol | 59-02-9 | sc-214454 sc-214454A sc-214454B | 10 g 25 g 100 g | $42.00 $61.00 $138.00 | ||
Vitamin E is a well-known antioxidant that protects cellular membranes from oxidative damage. By preserving hepatocyte membrane integrity and function, Vitamin E might indirectly support FIC1 function, as it relies on a stable membrane environment for its activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, like EGCG, has various hepatoprotective and anti-inflammatory effects. While its direct effect on FIC1 is not known, curcumin might indirectly support FIC1 function by improving liver health and reducing inflammatory damage, thus maintaining a conducive environment for FIC1's activity. | ||||||
Miltefosine | 58066-85-6 | sc-203135 | 50 mg | $79.00 | 8 | |
Miltefosine is a phospholipid analogue used primarily as an antileishmanial drug. It might affect cellular phospholipid composition and metabolism, potentially influencing FIC1 activity indirectly by altering the lipid environment in which it operates. | ||||||
Bezafibrate | 41859-67-0 | sc-204650B sc-204650 sc-204650A sc-204650C | 500 mg 1 g 5 g 10 g | $30.00 $45.00 $120.00 $200.00 | 5 | |
Bezafibrate is a fibric acid derivative used as a lipid-lowering agent that also affects bile acid metabolism. By improving lipid metabolism and potentially bile composition, bezafibrate might indirectly support FIC1 activity, particularly in maintaining proper bile acid and phospholipid balance. | ||||||