FBXW2 Activators
FBXW2 Activators encompass a selection of chemical compounds that influence cellular signaling pathways, indirectly enhancing the ubiquitin-proteasome system's activity where FBXW2 plays a crucial role. For instance, SKF-96365 and BAPTA-AM, by modulating calcium signaling, indirectly augment the functional activity of FBXW2, as calcium is a known regulator of ubiquitination processes which FBXW2 is involved in. Similarly, proteasome inhibitors like MG-132 and ALLN lead to the accumulation of ubiquitinated proteins, indirectly necessitating enhanced activity of FBXW2 by providing a greater substrate pool for this E3 ubiquitin ligase to target. PIK-93 and PD-98059, acting as inhibitors of phosphatidylinositol 4-kinase and MEK respectively, may result in an increased demand for FBXW2-mediated ubiquitination, as these pathways influence protein trafficking and signaling. Additionally, inhibitors such as Z-Leu-Leu-Leu-al and E64d stabilize proteins that could become substrates for FBXW2, indirectly enhancing its role in protein turnover.
Furthermore, SP600125, by inhibiting JNK activity, potentially shifts cellular signaling dynamics in favor of pathways where FBXW2's ubiquitin ligase activity is critical.PD-150606 and NSC 23766, with their roles in chelating intracellular calcium and inhibiting Rac1, respectively, can lead to alterations in calcium-dependent and cytoskeletal-associated signaling processes, which are part of the cellular contexts where FBXW2's activity is likely to be heightened. Finally, Necrostatin-1, by impeding RIPK1, may indirectly upregulate FBXW2's function in tagging proteins for degradation that are implicated in cell death pathways. Collectively, these activators, through their targeted effects on various cellular processes, facilitate the enhancement of FBXW2-mediated ubiquitination without directly affecting its expression levels or requiring its direct activation, underlining their role in fine-tuning the protein degradation machinery to which FBXW2 is a central contributor.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $103.00 $158.00 $397.00 $656.00 | 2 | |
SKF-96365 is an inhibitor of receptor-mediated calcium entry and store-operated calcium entry, which may indirectly increase the activity of FBXW2 by altering calcium signaling, a pathway known to be involved in the regulation of protein ubiquitination processes that FBXW2 is a part of. | ||||||
PIK-93 | 593960-11-3 | sc-364588 | 5 mg | $255.00 | ||
PIK-93 is a phosphatidylinositol 4-kinase inhibitor, which can modulate the phosphoinositide signaling pathway, indirectly increasing the need for FBXW2's role in protein ubiquitination related to membrane trafficking. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD-98059 is an MEK inhibitor that can influence the MAPK/ERK pathway, potentially leading to altered protein transcription profiles that favor the activation of the ubiquitination pathway involving FBXW2. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor, which may modulate the JNK signaling pathway, leading to an increase in ubiquitination activity where FBXW2 could play a role. | ||||||
PD 150606 | 179528-45-1 | sc-222133 sc-222133A | 5 mg 25 mg | $118.00 $403.00 | 18 | |
PD-150606 is an intracellular calcium chelator that can modulate calcium-dependent signaling pathways, potentially affecting protein ubiquitination where FBXW2 is involved. | ||||||
NSC 23766 | 733767-34-5 | sc-204823 sc-204823A | 10 mg 50 mg | $151.00 $609.00 | 75 | |
NSC 23766 is a Rac1 inhibitor that can modulate cytoskeletal organization, possibly increasing FBXW2's role in ubiquitination related to membrane trafficking and signaling. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
BAPTA-AM is a cell-permeable calcium chelator, which can influence calcium signaling and indirectly enhance the ubiquitination process involving FBXW2. | ||||||
E-64 | 66701-25-5 | sc-201276 sc-201276A sc-201276B | 5 mg 25 mg 250 mg | $281.00 $947.00 $1574.00 | 14 | |
E64d is a broad-spectrum cysteine protease inhibitor that may indirectly enhance FBXW2 activity by increasing the number of ubiquitinated proteins that FBXW2 could target. | ||||||
Necrostatin-1 | 4311-88-0 | sc-200142 sc-200142A | 20 mg 100 mg | $94.00 $343.00 | 97 | |
Necrostatin-1 is an inhibitor of RIPK1, which plays a role in necroptosis. By inhibiting RIPK1, it may indirectly enhance the activity of FBXW2 in the ubiquitination of proteins related to cell death signaling. | ||||||