Molecular structure of PD 150606, CAS Number: 179528-45-1
PD 150606 (CAS 179528-45-1)
See product citations (18)
Alternate Names:
3-(4-Iodophenyl)-2-mercapto-(Z)-2-propenoic Acid; PD 150,606
Application:
PD 150606 is a cell-permeable, non-competitive, selective, non-peptide inhibitor directed at the Ca2+ binding sites of calpain.
CAS Number:
179528-45-1
Molecular Weight:
306.1
Molecular Formula:
C9H7IO2S
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PD 150606 is a cell-permeable, non-competitive, selective, non-peptide Ca2+ dependent calpain inhibitor for calpain-1 and for calpain-2 directed towards the Ca2+ binding sites of calpain. It may act to decrease hypertrophy and inhibit proteolytic activity at all instances. PD 150606 in vitro treated human metastatic melanoma cells displayed a reduction in both effector caspase 3/7 activation and cellular detachment. It has also been observed to inhibit Ca2+ and calyculin A induced sperm motility of the fowl.
PD 150606 (CAS 179528-45-1) References
- Differential effects of calpain inhibitors on hypertrophy of cardiomyocytes. | Pollack, JR., et al. 2003. Mol Cell Biochem. 251: 47-50. PMID: 14575303
- Effects of calpain and Rho-kinase inhibitors on the acrosome reaction and motility of fowl spermatozoa in vitro. | Ashizawa, K., et al. 2006. Reproduction. 131: 71-9. PMID: 16388011
- Caspase-dependent and -independent pathways for cadmium-induced apoptosis in cultured kidney proximal tubule cells. | Lee, WK., et al. 2006. Am J Physiol Renal Physiol. 291: F823-32. PMID: 16597613
- Caspases and calpain are independent mediators of cisplatin-induced endothelial cell necrosis. | Dursun, B., et al. 2006. Am J Physiol Renal Physiol. 291: F578-87. PMID: 16622172
- Cross-talk between calpain and caspase-3/-7 in cisplatin-induced apoptosis of melanoma cells: a major role of calpain inhibition in cell death protection and p53 status. | Del Bello, B., et al. 2007. Oncogene. 26: 2717-26. PMID: 17130844
- Overexpression of TRPC3 increases apoptosis but not necrosis in response to ischemia-reperfusion in adult mouse cardiomyocytes. | Shan, D., et al. 2008. Am J Physiol Cell Physiol. 294: C833-41. PMID: 18184877
- The cytoprotective action of the potassium channel opener BMS-191095 in C2C12 myoblasts is related to the modulation of calcium homeostasis. | Malinska, D., et al. 2010. Cell Physiol Biochem. 26: 235-46. PMID: 20798507
- Calpain inhibitors exhibit matrix metalloproteinase-2 inhibitory activity. | Ali, MA., et al. 2012. Biochem Biophys Res Commun. 423: 1-5. PMID: 22575511
- Cleavage of IκBα by calpain induces myocardial NF-κB activation, TNF-α expression, and cardiac dysfunction in septic mice. | Li, X., et al. 2014. Am J Physiol Heart Circ Physiol. 306: H833-43. PMID: 24441549
- Role of calcium and calpain in the downregulation of voltage-gated sodium channel expression by the pyrethroid pesticide deltamethrin. | Magby, JP. and Richardson, JR. 2015. J Biochem Mol Toxicol. 29: 129-34. PMID: 25358543
- Targeting microparticle biogenesis: a novel approach to the circumvention of cancer multidrug resistance. | Roseblade, A., et al. 2015. Curr Cancer Drug Targets. 15: 205-14. PMID: 25714701
- Calpain 1 regulates TGF-β1-induced epithelial-mesenchymal transition in human lung epithelial cells via PI3K/Akt signaling pathway. | Tan, WJ., et al. 2017. Am J Transl Res. 9: 1402-1409. PMID: 28386365
- The human blood parasite Schistosoma mansoni expresses extracellular tegumental calpains that cleave the blood clotting protein fibronectin. | Wang, Q., et al. 2017. Sci Rep. 7: 12912. PMID: 29018227
- Lysosomal permeabilization and endoplasmic reticulum stress mediate the apoptotic response induced after photoactivation of a lipophilic zinc(II) phthalocyanine. | Chiarante, N., et al. 2018. Int J Biochem Cell Biol. 103: 89-98. PMID: 30130653
- Early Deсline in Rat Soleus Passive Tension with Hindlimb Unloading: Inactivation of Cross-bridges or Activation of Calpains? | Petrova, IO., et al. 2018. Dokl Biochem Biophys. 481: 205-207. PMID: 30168060
Inhibitor of:
4930511M11Rik, Calpain, Calpain 1, Calpain 15_Solh, Calpain 2, Calpain II, CAP2, caspase-5, CESK1, ERp27, KLHL11, LONRF2, LRRC42, reaper, RNF181, TATDN2, TMEM170, Torsin2A, TRUNDD, and VibH.Activator of:
Calpain 14, FBXW2, and LONRF1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PD 150606, 5 mg | sc-222133 | 5 mg | $118.00 | |||
PD 150606, 25 mg | sc-222133A | 25 mg | $403.00 |