FBL3A Activators
FBL3A Activators is a term that would encompass a range of compounds that can indirectly influence the function of the F-box/LRR-repeat protein 3 (FBL3A). These chemicals, which include MG-132, Lactacystin, LLnL, Epoxomicin, and MLN4924, operate by affecting the larger biochemical systems in which FBL3A plays a role, particularly the ubiquitin-proteasome system (UPS).
The UPS is responsible for the degradation of intracellular proteins, a crucial process in various cellular functions including cell cycle progression, signal transduction, and transcriptional regulation. FBL3A, as a component of the SCF (SKP1-cullin-F-box) ubiquitin ligase complex, participates in the marking of target proteins for degradation by the 26S proteasome. The compounds MG-132, Lactacystin, LLnL, and Epoxomicin are inhibitors of the proteasome, an enzyme complex that plays the final and crucial step in the UPS. By blocking the activity of the proteasome, these compounds can indirectly affect the function of FBL3A. MLN4924 operates differently, as an inhibitor of the NEDD8-activating enzyme (NAE). NEDD8 is a ubiquitin-like protein that modifies cellular targets in a process called neddylation, which is parallel to ubiquitination. By inhibiting NAE and thus the neddylation process, MLN4924 can indirectly influence ubiquitin-dependent processes in which FBL3A may be involved.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG-132 is a potent, reversible, and cell-permeable proteasome inhibitor. It blocks the proteolytic activity of the 26S proteasome complex. By inhibiting proteasomal degradation, it can indirectly affect FBXL3's function and the ubiquitin-proteasome pathway. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $188.00 $575.00 | 60 | |
Lactacystin is a specific and potent inhibitor of the proteasome, which is the major non-lysosomal protease responsible for intracellular protein degradation. It directly inhibits the proteolytic function of the 20S proteasome and therefore can indirectly affect FBXL3's role in protein degradation. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $137.00 $219.00 $449.00 $506.00 | 19 | |
Epoxomicin is a potent, selective, and irreversible proteasome inhibitor. It covalently binds to the 20S proteasome and blocks its activity, which can indirectly modulate FBXL3's function. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $286.00 | 1 | |
MLN4924 is a small molecule inhibitor of NEDD8-activating enzyme (NAE), which is involved in protein neddylation, a process parallel to ubiquitination. By inhibiting neddylation, MLN4924 can indirectly influence ubiquitination processes that FBXL3 may be involved in. | ||||||