FAN Inhibitors
FAN Inhibitors refers to a category of chemical compounds developed to target and modulate the activity of proteins or enzymes associated with the Fanconi anemia (FA) pathway. The Fanconi anemia pathway is a crucial cellular mechanism responsible for repairing damaged DNA, particularly DNA interstrand crosslinks. Failure in the proper functioning of the FA pathway can lead to genomic instability. Inhibitors of this pathway are designed to interfere with the activity of specific proteins involved in the FA pathway, potentially disrupting the DNA repair process.
Structurally, FAN Inhibitors are carefully designed to interact with key proteins or enzymes within the FA pathway.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $65.00 $99.00 $140.00 | 85 | |
Mitomycin C is a chemotherapeutic agent that induces DNA crosslinks. It's commonly used to test for Fanconi anemia because FA cells are hypersensitive to it. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
Cisplatin is a chemotherapy drug that forms intrastrand DNA crosslinks. FA pathway is involved in the repair of these lesions. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Hydroxyurea inhibits ribonucleotide reductase, causing replication stress and activating the FA pathway. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $206.00 $299.00 $485.00 | 10 | |
Olaparib inhibits PARP, another enzyme involved in DNA repair. While not a direct FA inhibitor, it's used in cancers with DNA repair deficiencies. | ||||||
Veliparib | 912444-00-9 | sc-394457A sc-394457 sc-394457B | 5 mg 10 mg 50 mg | $178.00 $270.00 $712.00 | 3 | |
Another PARP inhibitor. Similarly, it targets cells with compromised DNA repair capabilities. | ||||||
Talazoparib | 1207456-01-6 | sc-507440 | 10 mg | $795.00 | ||
A potent PARP inhibitor that traps PARP on damaged DNA. | ||||||
Rucaparib | 283173-50-2 | sc-507419 | 5 mg | $150.00 | ||
Another drug in the class of PARP inhibitors. | ||||||
Niraparib | 1038915-60-4 | sc-507492 | 10 mg | $150.00 | ||
A PARP inhibitor studied in the research of ovarian cancer. | ||||||
Gallium(III) nitrate solution, Ga 9-10% w/w | 13494-90-1 | sc-300758 sc-300758A | 50 g 250 g | $135.00 $595.00 | ||
Although not specific, gallium nitrate has been shown to inhibit the FA/BRCA pathway. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, from turmeric, has been shown in some studies to potentially modulate the FA pathway, though the data is preliminary. | ||||||