FAM35A Activators
FAM35A activators belong to a specialized class of chemical compounds that interact with the human protein known as FAM35A. FAM35A, short for family with sequence similarity 35 member A, is a protein that plays a role in cellular processes. The compounds that activate FAM35A are designed to modulate the protein's activity within the complex network of intercellular signaling pathways. Activation of FAM35A by these molecules can lead to alterations in the protein's behavior and function, which may have various downstream effects on cellular functions. The exact mechanisms through which FAM35A activators exert their influence can involve a range of biochemical interactions, including changes in protein conformation, the modulation of protein-protein interactions, or the alteration of the protein's expression levels within the cell.
The study and development of FAM35A activators require an in-depth understanding of both the structure and function of the FAM35A protein. Structural biology techniques such as X-ray crystallography, NMR spectroscopy, and cryo-electron microscopy can be employed to determine the three-dimensional structure of FAM35A, providing insights into the potential binding sites for activators. Biochemical assays are then used to screen for compounds that can bind to the protein and activate it. Such activators often originate from diverse chemical libraries and may include small molecules, peptides, or other biologically active compounds. Discovery of FAM35A activators is typically an iterative process, involving the synthesis and testing of various chemical entities, followed by optimization based on structure-activity relationships. The identification of FAM35A activators sheds light on the protein's role in cellular pathways and provides a tool for probing the biological functions of FAM35A.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG acts as an antioxidant and can modulate cellular signaling pathways by inhibiting specific kinases. This can lead to the enhanced activation of FAM35A as it may be involved in pathways related to cellular stress responses. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is known to activate protein kinase C (PKC), which is involved in various signaling cascades. PKC activation can enhance FAM35A function indirectly by affecting cellular pathways that rely on PKC signaling where FAM35A may play a role. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P interacts with its receptors to activate intracellular signaling pathways, including those regulating cell survival and proliferation. Such pathways can indirectly enhance the activity of FAM35A in processes like DNA damage response. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, indirectly enhancing FAM35A activity by stimulating calcium-dependent signaling pathways with which FAM35A could interact. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates sirtuin 1 (SIRT1), a protein deacetylase, which can lead to the enhancement of FAM35A activity by modulating cellular pathways involved in DNA repair and genome stability where FAM35A is implicated. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can modulate multiple signaling pathways, including those affecting cell survival and apoptosis. Through these pathways, Curcumin can indirectly enhance the function of FAM35A in DNA damage response and repair. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a phosphatidylinositol 3-kinase (PI3K) inhibitor, which can lead to the activation of alternate signaling pathways that may enhance the activity of FAM35A in processes such as DNA repair. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a MEK inhibitor that may shift the signaling equilibrium in cells, potentially enhancing pathways that involve FAM35A in DNA damage response and repair mechanisms. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, which can lead to the activation of autophagy and other cellular stress responses. This inhibition may indirectly enhance FAM35A function in related pathways. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum kinase inhibitor that can lead to the activation of cellular pathways that are less sensitive to its inhibitory effects, potentially enhancing the function of FAM35A in such pathways. | ||||||