FAM173B Activators
FAM173B Activators work through a variety of molecular mechanisms to enhance the protein's functional activity. Some of these activators function by increasing the levels of intracellular cAMP, which in turn activates protein kinase A (PKA). The activated PKA can then phosphorylate FAM173B, resulting in its enhanced activity. This phosphorylation can occur through direct stimulation of adenylyl cyclase by certain compounds or through inhibition of phosphodiesterases (PDEs), which normally break down cAMP. By preventing cAMP degradation, these activators indirectly lead to higher PKA activity and subsequent phosphorylation of FAM173B. Additionally, agonists that stimulate G-protein-coupled receptors also increase cAMP levels, which similarly facilitates the activation of PKA. The consequence of this cascade is the phosphorylation and activation of FAM173B, aligning with the function of these activators.
Another set of activators exerts their influence through modulation of sirtuin activity. Sirtuins, which are NAD+-dependent deacetylases, can target FAM173B to deacetylate it, potentially leading to an increase in FAM173B's activity. Certain activators supply precursors that boost the intracellular levels of NAD+, thereby enhancing sirtuin activity and the subsequent deacetylation of FAM173B. Others, through their direct activation of sirtuins, can lead to similar outcomes.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Beta-adrenergic agonist that elevates cAMP by stimulating adenylyl cyclase, subsequently activating PKA that may target FAM173B for phosphorylation and activation. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
PDE inhibitor that prevents cAMP breakdown, thereby potentiating PKA activation, which can result in enhanced phosphorylation and activation of FAM173B. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
PDE4 inhibitor that increases cAMP levels, leading to PKA activation. PKA may then phosphorylate and activate FAM173B. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Prostaglandin that activates G-protein-coupled receptors coupled to adenylyl cyclase, increasing cAMP and PKA activity, possibly leading to FAM173B activation. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Adrenergic receptor agonist that increases cAMP levels, leading to PKA activation. PKA may phosphorylate FAM173B, enhancing its functional activity. | ||||||
Nicotinamide riboside | 1341-23-7 | sc-507345 | 10 mg | $411.00 | ||
NAD+ precursor that can influence sirtuin activity. Sirtuins may deacetylate FAM173B, which can increase its activity. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $105.00 $250.00 | 8 | |
PDE5 inhibitor that raises cAMP levels, leading to PKA-mediated phosphorylation and potential activation of FAM173B. | ||||||
Glucagon trifluoroacetic acid salt | 9007-92-5 (free base) | sc-495801 | 1 mg | $480.00 | ||
Hormone that activates G-protein-coupled receptors to increase cAMP levels, promoting PKA activation and potential phosphorylation of FAM173B. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Activates sirtuins that may deacetylate FAM173B, potentially enhancing its activity. | ||||||