FAM169B Inhibitors
FAM169B inhibitors represent a class of chemical compounds specifically designed to target and inhibit the function of the FAM169B protein. The FAM169B protein, coded by the FAM169B gene, is presumed to play a role in cellular processes, although its precise biological functions remain to be fully elucidated. Inhibitors of FAM169B would thus be tailored to interfere with the protein's activity, binding to FAM169B directly or indirectly affecting pathways that regulate its function. These inhibitors might work by altering the protein's conformation, blocking its active sites, or preventing its interaction with other cellular components necessary for its function. Since FAM169B is involved in complex intracellular networks, its inhibitors would be designed after meticulous studies of the protein's structure and the pathways it influences, ensuring specificity and efficacy in the inhibition process.
The design and action of FAM169B inhibitors would be a product of cutting-edge research in molecular biology and chemistry, focusing on the minutiae of the protein's role and its interaction within the cell. The development process of these inhibitors includes in silico modeling and experimental validation to ensure that the chemical compounds not only bind to FAM169B but also do so in a way that effectively hampers its activity. This could involve preventing the protein from undergoing necessary post-translational modifications or obstructing the physical interaction between FAM169B and other proteins or DNA sequences it might normally bind to. The specificity of these inhibitors is crucial, as off-target effects could disrupt other cellular functions. By exclusively targeting FAM169B, these inhibitors would serve as powerful tools for dissecting the protein's role in cell biology and for understanding the molecular details of the processes in which it is involved.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin binds to FKBP12 and the complex inhibits mTOR, a kinase important in the PI3K/AKT pathway. As mTOR is involved in protein synthesis and cell proliferation, its inhibition can lead to reduced activity of numerous proteins, potentially including FAM169B if it is downstream of mTOR signaling. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a specific inhibitor of phosphoinositide 3-kinases (PI3Ks), which are upstream of the AKT signaling pathway. By inhibiting PI3K, the subsequent AKT phosphorylation and activation are reduced, which could lead to decreased activity of proteins regulated by this pathway, such as FAM169B if FAM169B is a downstream effector. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of MEK, which inhibits the ERK/MAPK pathway. This pathway is involved in cell growth and differentiation. Inhibition of MEK, and therefore the ERK/MAPK pathway, could indirectly decrease the activity of FAM169B if it is implicated in this signaling cascade. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is another MEK inhibitor that works similarly to PD98059. It non-competitively inhibits MEK1/2, leading to a decrease in ERK pathway activity. If FAM169B activity is modulated by the ERK pathway, inhibition by U0126 could result in decreased FAM169B function. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent PI3K inhibitor. It covalently binds to and inhibits PI3K, leading to a decrease in protein kinase B (AKT) signaling. As with LY294002, if FAM169B activity is related to the PI3K/AKT pathway, wortmannin-induced inhibition could result in decreased FAM169B activity. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $102.00 $138.00 | 14 | |
Triciribine is an AKT inhibitor that prevents its phosphorylation and activation. By inhibiting AKT, it may lead to a decrease in the phosphorylation and activation of downstream proteins, potentially including FAM169B if it is an AKT substrate. | ||||||
Spautin-1 | 1262888-28-7 | sc-507306 | 10 mg | $165.00 | ||
Spautin-1 is an autophagy inhibitor that specifically targets the degradation of class III PI3K complexes. By preventing autophagy, it may indirectly affect the turnover of various cellular proteins, including possibly FAM169B if it is subject to autophagic degradation. | ||||||
PP242 | 1092351-67-1 | sc-301606A sc-301606 | 1 mg 5 mg | $56.00 $169.00 | 8 | |
PP242 is a selective mTOR inhibitor that blocks both mTORC1 and mTORC2 complexes. By inhibiting mTORC1/2, PP242 can decrease the phosphorylation of downstream targets involved in translation and cell growth, potentially reducing the activity of FAM169B if it is associated with mTOR pathways. | ||||||
Torin 1 | 1222998-36-8 | sc-396760 | 10 mg | $240.00 | 7 | |
Torin 1 is another selective mTOR inhibitor that targets both mTORC1 and mTORC2. It leads to a broad inhibition of the mTOR pathway, which could affect the activity of proteins like FAM169B if they are downstream of mTOR signaling. | ||||||
AZD8055 | 1009298-09-2 | sc-364424 sc-364424A | 10 mg 50 mg | $160.00 $345.00 | 12 | |
AZD8055 is a potent ATP-competitive inhibitor of mTOR kinase. It inhibits both mTORC1 and mTORC2 signaling pathways, which may result in reduced activity of downstream proteins. If FAM169B is influenced by mTOR signaling, AZD8055 inhibition could lead to decreased FAM169B activity. | ||||||