FAM155A Inhibitors
Chemical inhibitors of FAM155A operate through diverse molecular mechanisms to impede the functional activity of this protein. Alsterpaullone, a cyclin-dependent kinase inhibitor, can arrest cell cycle progression, thereby indirectly influencing the function of FAM155A, which is understood to be involved in cell cycle control. Similarly, SB-216763 targets glycogen synthase kinase 3 (GSK-3), a key enzyme in cellular pathways linked to protein synthesis and cellular structure. As GSK-3 is inhibited, the normal functioning of FAM155A within these pathways can be disrupted. Thapsigargin, by inhibiting the SERCA pump, leads to an increase in cytosolic calcium levels, which can disturb calcium-dependent signaling pathways and thus inhibit the activity of calcium-sensitive proteins like FAM155A.
Moreover, PD-98059 and U0126, both inhibitors of MEK, can stifle the ERK pathway, which is connected to cellular proliferation and differentiation signals. FAM155A, potentially being part of this signaling cascade, can be functionally inhibited when this pathway is obstructed. LY-294002 and Wortmannin are PI3K inhibitors; their action can inhibit the Akt signaling pathway, which is implicated in regulating numerous cellular processes, including those in which FAM155A may play a role. SP600125, a JNK inhibitor, can interfere with stress response pathways, potentially leading to the functional inhibition of FAM155A. Conversely, Rapamycin, by inhibiting mTOR, disrupts a central pathway crucial for cell growth, which can affect the function of growth-associated proteins like FAM155A. Staurosporine broadly targets protein kinases, which could lead to the inhibition of various signaling pathways and thus impair proteins reliant on phosphorylation, including FAM155A. Lastly, Y-27632 and PP2 target the ROCK pathway and Src family kinases, respectively, both of which are involved in important signaling cascades; their inhibition can lead to altered regulation and function of FAM155A within these pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $67.00 $306.00 | 2 | |
Alsterpaullone is a known cyclin-dependent kinase inhibitor that can inhibit cell cycle progression. Inhibition of these kinases can disrupt the cell cycle, which family with sequence similarity 155 member A (FAM155A) is understood to influence, leading to the functional inhibition of FAM155A as a result of disrupted cell cycle control. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $70.00 $198.00 | 18 | |
SB-216763 acts as a glycogen synthase kinase 3 (GSK-3) inhibitor. As GSK-3 is implicated in multiple cellular pathways including those related to protein synthesis and cellular structure, inhibition of GSK-3 can disrupt the proper functioning of proteins like FAM155A that are part of these pathways. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor that leads to increased cytosolic calcium levels. Elevated calcium levels can disrupt calcium-dependent signaling pathways, which can inhibit the activity of proteins like FAM155A that may rely on calcium signaling for their proper function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD-98059 is an inhibitor of MEK, which in turn inhibits the ERK pathway. The ERK pathway is involved in cellular proliferation and differentiation signals that proteins like FAM155A may be part of. Inhibition of this pathway can thus lead to the functional inhibition of FAM155A. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, which is part of the stress-activated protein kinase pathway. Inhibiting JNK can interfere with stress response pathways that FAM155A may be involved in, leading to its functional inhibition. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2, which are upstream of ERK in the MAPK pathway. Inhibiting MEK1/2 can inhibit the ERK pathway, thereby inhibiting downstream proteins such as FAM155A that are part of this signaling cascade. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent PI3K inhibitor, and by inhibiting PI3K, it can inhibit downstream signaling pathways, including those involving FAM155A, potentially resulting in the functional inhibition of FAM155A. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor and by inhibiting mTOR, it can disrupt the mTOR signaling pathway which is crucial for cell growth and proliferation. As FAM155A is implicated in cellular growth, this inhibition can lead to its functional inhibition. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum protein kinase inhibitor. By inhibiting protein kinases that participate in various signaling pathways, it can interfere with the activity of proteins like FAM155A that rely on phosphorylation for their function. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a ROCK inhibitor, which can inhibit the Rho/ROCK pathway. Since the Rho/ROCK pathway is involved in cytoskeleton organization and cell motility, inhibition of this pathway can lead to the functional inhibition of associated proteins like FAM155A. | ||||||