eyes absent Activators
The realm of eyes absent (Eya) protein activators is rooted in the intricate interactions of signaling pathways that influence its function. Eya, known for its phosphatase activity and role as a transcriptional co-activator, operates in tandem with an array of cellular processes, most prominently the Hippo signaling pathway. Verteporfin and XMU-MP-1, for instance, modulate components of the Hippo pathway, thereby influencing the activity and interactions of Eya. By disrupting the YAP-TEAD interaction or inhibiting MST1/2 kinases, these compounds can lead to an upregulation of YAP/TAZ activity, resulting in a change in the interaction dynamics of Eya within the cellular environment.
Another facet of Eya activation delves into the crosstalk of the Hippo pathway with other signaling cascades. Compounds like Dorsomorphin, CHIR-99021, and Y-27632 exemplify this interplay by targeting BMP signaling, Wnt/β-catenin signaling, or Rho-associated protein kinases respectively. Each of these molecules, by acting on their primary targets, indirectly shift the balance of Hippo signaling, influencing Eya's function. Additionally, the interplay between mTOR signaling, as seen with compounds OSI-027, KU-0063794, and AZD8055, and the Hippo pathway further illustrates the nuanced layers of interactions that can modulate Eya. Every compound, in its unique manner, tweaks the signaling dynamics in the cellular environment, leading to an indirect influence on Eya's role in organogenesis and other developmental processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Verteporfin | 129497-78-5 | sc-475698 sc-475698A | 10 mg 100 mg | $347.00 $2710.00 | 5 | |
Verteporfin disrupts the YAP-TEAD interaction in the Hippo pathway. By influencing YAP activity, Eya, which can interact with YAP in certain contexts, is indirectly modulated. | ||||||
BML-275 | 866405-64-3 | sc-200689 sc-200689A | 5 mg 25 mg | $94.00 $348.00 | 69 | |
Dorsomorphin inhibits BMP signaling. With BMP pathways interacting with Hippo signaling, Eya function can be indirectly modulated through changes in cellular context. | ||||||
GSK-3 Inhibitor XVI | 252917-06-9 | sc-221691 sc-221691A | 5 mg 25 mg | $153.00 $520.00 | 4 | |
CHIR-99021 activates Wnt/β-catenin signaling. Through cross-talk between Wnt and Hippo pathways, Eya's interactions in the cellular milieu are indirectly influenced. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 inhibits Rho-associated protein kinases (ROCK). As ROCK can influence the Hippo pathway, its inhibition indirectly modulates Eya through YAP/TAZ activity shifts. | ||||||
OSI-027 | 936890-98-1 | sc-364557 sc-364557A | 10 mg 50 mg | $428.00 $1163.00 | 1 | |
OSI-027 inhibits mTORC1 and mTORC2. mTOR signaling crosstalk with Hippo can influence Eya's indirect modulation by altering the cellular protein interaction landscape. | ||||||
Stat3 Inhibitor VI, S3I-201 | 501919-59-1 | sc-204304 | 10 mg | $148.00 | 104 | |
S3I-201 inhibits Stat3. As Stat3 signaling can interface with the Hippo pathway, its inhibition indirectly affects Eya function. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
Go6983 inhibits PKC. PKC can influence the Hippo pathway, leading to indirect modulation of Eya through changes in the pathway’s dynamics. | ||||||
PIK-75, hydrochloride | 372196-77-5 | sc-296089 sc-296089A | 1 mg 5 mg | $28.00 $122.00 | ||
PIK-75 inhibits PI3K p110α. PI3K signaling crosstalk with the Hippo pathway can indirectly influence Eya’s cellular interactions and function. | ||||||
KU 0063794 | 938440-64-3 | sc-361219 | 10 mg | $209.00 | ||
KU-0063794 inhibits mTOR. By modulating mTOR and its crosstalk with Hippo, Eya's function and interactions can be indirectly affected. | ||||||
AZD8055 | 1009298-09-2 | sc-364424 sc-364424A | 10 mg 50 mg | $160.00 $345.00 | 12 | |
AZD8055 targets mTOR kinase. This modulation of mTOR signaling can indirectly influence Eya via altered signaling dynamics and protein interactions. | ||||||