Exportin (XPO) Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ratjadone A, Synthetic | 163564-92-9 | sc-203234 | 2 µg | $168.00 | 2 | |
Inhibits CRM1, the major nuclear export protein, indirectly impacting Exportins function. Ratjadone A blocks the CRM1-RanGTP interaction, disrupting the general nuclear export pathway and potentially affecting Exportins-mediated export of pre-miRNAs. | ||||||
KPT185 | 1333151-73-7 | sc-487916 | 10 mg | $220.00 | ||
Another Exportin inhibitor, KPT-185 disrupts CRM1-mediated nuclear export, indirectly modulating Exportins function by affecting shared export pathways. It interferes with the CRM1-RanGTP interaction, potentially influencing the export of pre-miRNAs by Exportins. | ||||||
Chromomycin A3 | 7059-24-7 | sc-200907 | 10 mg | $255.00 | ||
Binds to G-quadruplex structures in DNA, influencing the processing of pre-miRNAs and potentially indirectly impacting Exportins function. Chromomycin A3's interaction with DNA structures can alter the accessibility of pre-miRNAs for Exportins-mediated nuclear export. | ||||||
2-Methoxyestradiol | 362-07-2 | sc-201371 sc-201371A | 10 mg 50 mg | $70.00 $282.00 | 6 | |
Inhibits HIF-1α, potentially indirectly impacting Exportins as HIF-1α is implicated in miRNA biogenesis. 2-Methoxyestradiol disrupts the HIF-1α pathway, potentially influencing the processing and availability of pre-miRNAs for Exportins-mediated nuclear export. | ||||||
Verdinexor | 1392136-43-4 | sc-492602 | 5 mg | $395.00 | ||
Inhibits Exportin-mediated nuclear export of tumor suppressors. | ||||||
Fexofenadine | 83799-24-0 | sc-218475 | 100 mg | $292.00 | 1 | |
Selective inhibitor of Exportin, impairs cargo protein export. | ||||||