Ratjadone A, Synthetic (CAS 163564-92-9)

Ratjadone A, a synthetic compound with CAS number 163564-92-9, is a macrocyclic polyketide known for its distinct mechanism of action as a potent inhibitor of the nuclear export of proteins and RNA in eukaryotic cells. This compound specifically interacts with exportin-1 (XPO1), a key nuclear export protein responsible for transporting various molecular cargoes from the nucleus to the cytoplasm. By binding to XPO1, Ratjadone A effectively blocks the export pathway, leading to the accumulation of these molecules within the nucleus, which can disrupt normal cellular functions and signaling pathways. In research contexts, Ratjadone A is utilized extensively to study the nuclear export mechanisms of cells, providing insights into the fundamental processes of cellular regulation and communication. Researchers employ this molecule to probe the dynamics of nuclear-cytoplasmic transport, including the roles of specific proteins and RNA molecules in cellular processes such as gene expression regulation and signal transduction. This compound is also used to explore the consequences of interrupted nuclear export on cell physiology, offering a deeper understanding of cellular response mechanisms to external and internal stimuli. Through these studies, Ratjadone A serves as a valuable tool in cellular and molecular biology, contributing to the advancement of knowledge in cellular trafficking and function.