Evx-2 Inhibitors
Chemical inhibitors of Evx-2 act by disrupting the signaling pathways essential for the protein's function in developmental processes. Dorsomorphin, LDN-193189, DMH1, LDN-214117, K02288, ML347, and LDN-212854 are selective inhibitors that target the BMP signaling pathway, which is crucial for Evx-2's role in dorsal-ventral patterning during embryogenesis. These inhibitors achieve their effect by binding to BMP type I receptors such as ALK2, ALK3, and ALK6, thereby preventing the activation of these receptors and subsequent signaling that would typically lead to Evx-2 activity. For example, Dorsomorphin and LDN-193189 are known to selectively inhibit ALK2 and ALK3 receptors, leading to a decrease in BMP-mediated signaling and, consequently, the inhibition of Evx-2. Similarly, DMH1 and K02288 are potent in their action against these receptors, ensuring a broad inhibition of the BMP pathway and hence Evx-2. LDN-214117 and LDN-212854 specifically target ALK2, while ML347 extends its inhibition to ALK1, all contributing to the reduced function of Evx-2.
Parallel to BMP inhibitors, several compounds including SB-431542, A-83-01, and Vactosertib specifically inhibit the TGF-β signaling pathway, which also intersects with Evx-2's functional landscape. SB-431542 selectively inhibits ALK4, ALK5, and ALK7, which are part of the TGF-β superfamily, leading to a disruption of the signaling processes involved in various developmental patterns where Evx-2 is active. A-83-01 takes a similar approach by targeting ALK4, ALK5, and ALK7, while Vactosertib focuses on ALK5 inhibition. Finally, the peptide Noggin binds directly to BMPs, preventing their interaction with BMP receptors and thus curtailing BMP signaling, which is essential for the proper functioning of Evx-2. Collectively, these chemicals inhibit Evx-2 by either directly blocking the BMP ligands or by targeting the receptors associated with the BMP/TGF-β signaling pathways, thereby altering the developmental signals that require Evx-2's activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
BML-275 | 866405-64-3 | sc-200689 sc-200689A | 5 mg 25 mg | $94.00 $348.00 | 69 | |
Dorsomorphin inhibits BMP signaling, which is an important pathway for the dorsal-ventral patterning during embryogenesis. As Evx-2 is associated with embryonic development and patterning, the inhibition of BMP signaling through Dorsomorphin can lead to the functional inhibition of Evx-2 by disrupting the embryonic developmental processes it is involved in. | ||||||
4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline | 1062368-24-4 | sc-476297 | 5 mg | $240.00 | ||
LDN-193189 is a selective BMP inhibitor. By inhibiting BMP type I receptors ALK2 and ALK3, which are upstream in the pathway where Evx-2 functions, LDN-193189 can disrupt the signaling required for the proper function of Evx-2 within the developmental processes. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB-431542 selectively inhibits the TGF-β superfamily type I activin receptor-like kinase receptors ALK4, ALK5, and ALK7. Since TGF-β signaling has a role in various developmental processes, the inhibition of this pathway can lead to a decrease in Evx-2 activity, as Evx-2 is implicated in the development and patterning mediated by TGF-β. | ||||||
DMH-1 | 1206711-16-1 | sc-361171 sc-361171B sc-361171A sc-361171C | 10 mg 25 mg 50 mg 100 mg | $209.00 $312.00 $620.00 $1026.00 | 2 | |
DMH1 is a selective BMP inhibitor, specifically against ALK2, ALK3, and ALK6. By inhibiting these receptors, DMH1 disrupts BMP signaling. Since Evx-2 is involved in developmental pathways where BMP signaling is crucial, the inhibition of this pathway by DMH1 can lead to the functional inhibition of Evx-2. | ||||||
LDN-214117 | 1627503-67-6 | sc-507451 | 5 mg | $165.00 | ||
LDN-214117 is another selective BMP inhibitor that blocks ALK2. By selectively targeting this receptor, LDN-214117 disrupts BMP-mediated signaling pathways. Given the role of BMP pathways in the regulation of developmental processes, the inhibition by LDN-214117 can lead to the functional inhibition of Evx-2. | ||||||
K02288 | 1431985-92-0 | sc-488981 | 5 mg | $330.00 | ||
K02288 is a potent and selective inhibitor of ALK2 and ALK3, which are receptors involved in BMP signaling. By inhibiting these receptors, K02288 disrupts the signaling pathways in which Evx-2 operates, leading to its functional inhibition due to the altered developmental signaling. | ||||||
LDN 193719 | 1062368-49-3 | sc-489383 | 10 mg | $189.00 | ||
LDN 193719 is a selective inhibitor of ALK1 and ALK2, which are BMP receptor kinases. Its inhibition of these receptors can impede BMP signaling pathways, which are essential for the developmental processes that involve Evx-2. Therefore, inhibition of BMP signaling by ML347 can functionally inhibit Evx-2. | ||||||
5-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | 1432597-26-6 | sc-476318 | 5 mg | $380.00 | ||
LDN-212854 is an inhibitor of BMP receptor ALK2. By targeting ALK2, it impedes BMP signaling. The inhibition of this pathway can lead to the functional inhibition of Evx-2 by altering the signaling required for Evx-2's role in developmental patterning. | ||||||
A 83-01 | 909910-43-6 | sc-203791 sc-203791A | 10 mg 50 mg | $198.00 $795.00 | 16 | |
A-83-01 is a selective inhibitor of ALK5, ALK4, and ALK7, which are TGF-β superfamily receptors. The inhibition of these receptors can disrupt TGF-β signaling pathways where Evx-2 is implicated. Therefore, the functional inhibition of Evx-2 can occur due to the interference with these developmental signals. | ||||||
EW-7197 | 1352608-82-2 | sc-507465 | 5 mg | $345.00 | ||
Vactosertib is a TGF-β receptor kinase inhibitor that targets ALK5. By inhibiting ALK5, it disrupts TGF-β signaling pathways. Since Evx-2 is involved in developmental processes regulated by TGF-β signaling, the inhibition of this pathway by Vactosertib can lead to the functional inhibition of Evx-2. | ||||||