Evi-1 Inhibitors
Evi-1 inhibitors belong to a distinctive chemical class that specifically targets a protein known as Evi-1 (Ecotropic Viral Integration Site 1). Evi-1 is a transcription factor, meaning it plays a crucial role in regulating gene expression. It is involved in various cellular processes, including cell growth, differentiation, and development. Evi-1 is normally tightly controlled in healthy cells, but its dysregulation has been associated with several diseases. Evi-1 inhibitors are designed to modulate the activity of the Evi-1 protein by binding to it and disrupting its normal function. These inhibitors typically have a unique chemical structure that enables them to interact with specific regions of the Evi-1 protein. By doing so, they can interfere with the protein's ability to bind to DNA and initiate gene expression, thus altering the downstream signaling pathways.
The development of Evi-1 inhibitors involves a comprehensive understanding of the structure and function of the Evi-1 protein. Scientists employ various strategies, such as computer-aided drug design and high-throughput screening, to identify or design small molecules capable of selectively inhibiting Evi-1 activity. These inhibitors are then rigorously tested in studies to evaluate their effectiveness, safety, and pharmacokinetic properties. Evi-1 inhibitors have shown promise in experimental models, demonstrating the potential to modulate Evi-1-related biological processes. However, it is important to note that their chemical class is still under active research, and extensive investigations are ongoing to further elucidate their precise mechanisms of action and explore their potential applications.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(S)-2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-hydroxyphenyl)acetamide | 202590-98-5 | sc-501130 | 2.5 mg | $330.00 | ||
Also called OTX015, this compound is a small molecule inhibitor targeting BET bromodomains. By inhibiting BET proteins, including BRD4, OTX015 affects chromatin remodeling and transcriptional regulation, potentially impacting the expression of genes involved in pathways related to Evi-1. | ||||||
I-BET 151 Hydrochloride | 1300031-49-5 (non HCl Salt) | sc-391115 | 10 mg | $450.00 | 2 | |
I-BET151 is a small molecule inhibitor targeting BET bromodomains. By inhibiting BET proteins, I-BET151 affects chromatin remodeling and transcriptional regulation, potentially impacting the expression of genes involved in pathways related to Evi-1. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
JQ1 is a small molecule inhibitor that targets bromodomain-containing proteins, including BET proteins. By inhibiting BET proteins, JQ1 affects chromatin remodeling and transcriptional regulation, potentially impacting the expression of genes involved in pathways related to Evi-1. | ||||||
RVX 208 | 1044870-39-4 | sc-472700 | 10 mg | $340.00 | ||
RVX-208 is a BET inhibitor, selectively targeting BRD4. By inhibiting BRD4, RVX-208 modulates chromatin structure and transcriptional regulation, potentially influencing the expression of genes associated with Evi-1-related pathways. | ||||||
UNC1999 | 1431612-23-5 | sc-475314 | 5 mg | $142.00 | 1 | |
UNC1999 is a selective inhibitor of the histone methyltransferase G9a. By inhibiting G9a, UNC1999 modulates histone methylation, potentially impacting the epigenetic regulation of genes involved in pathways associated with Evi-1. | ||||||
GSK343 | 1346704-33-3 | sc-397025 sc-397025A | 5 mg 25 mg | $148.00 $452.00 | 1 | |
GSK343 is a selective inhibitor of the histone demethylase JMJD3. By inhibiting JMJD3, GSK343 modulates histone methylation patterns, potentially impacting the epigenetic regulation of genes involved in pathways associated with Evi-1. | ||||||
EPZ6438 | 1403254-99-8 | sc-507456 | 1 mg | $66.00 | ||
EPZ-6438 is a selective inhibitor of the histone methyltransferase EZH2. By inhibiting EZH2, EPZ-6438 modulates histone methylation, influencing the epigenetic regulation of genes associated with Evi-1-related pathways. | ||||||
CPI-360 | 1802175-06-9 | sc-507464 | 1 mg | $100.00 | ||
CPI-360 is a small molecule inhibitor of the histone methyltransferase EZH2. By inhibiting EZH2, CPI-360 modulates histone methylation patterns, potentially impacting the epigenetic regulation of genes involved in pathways associated with Evi-1. | ||||||