Date published: 2026-4-28

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ERR gamma Activators

Santa Cruz Biotechnology now offers a broad range of ERR gamma Activators for use in various applications. ERR gamma, or Estrogen-Related Receptor Gamma, is a crucial transcription factor within the nuclear receptor family that influences the expression of genes involved in energy homeostasis and mitochondrial function. The exploration of ERR gamma activators is significant in scientific research, particularly in studies of cellular metabolism and energy regulation. These activators are essential tools for understanding how metabolic pathways are coordinated at the cellular level, providing insights into the complex mechanisms of cellular energy production and consumption. In metabolic research, ERR gamma activators facilitate the study of mitochondrial biogenesis and the regulation of oxidative capacity in cells, which are fundamental for understanding metabolic efficiency and adaptation in various physiological and environmental conditions. Moreover, these compounds aid in the investigation of the genetic networks that modulate energy balance, offering a deeper understanding of cellular responses to metabolic stress. The role of ERR gamma in transcriptional regulation also extends to developmental biology, where it contributes to the differentiation and function of energy-dependent tissues. By enabling precise manipulation of ERR gamma activity, researchers can dissect its roles across different biological contexts, aiding in the unraveling of the intricate balance between energy production and expenditure necessary for cellular and organismal homeostasis. View detailed information on our available ERR gamma Activators by clicking on the product name.

Items 11 to 17 of 17 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Nicotinamide riboside

1341-23-7sc-507345
10 mg
$411.00
(0)

Nicotinamide riboside is a precursor of NAD+, which activates SIRT1. The activated SIRT1 deacetylates PGC-1α, leading to the upregulation of ERRγ transcriptional activity.

Berberine

2086-83-1sc-507337
250 mg
$92.00
1
(0)

Berberine is an AMPK activator. The activation of AMPK enhances PGC-1α activity, which in turn increases the transcriptional function of ERRγ.

Quercetin

117-39-5sc-206089
sc-206089A
sc-206089E
sc-206089C
sc-206089D
sc-206089B
100 mg
500 mg
100 g
250 g
1 kg
25 g
$11.00
$17.00
$110.00
$250.00
$936.00
$50.00
33
(2)

Quercetin is known to activate SIRT1. The activated SIRT1 deacetylates PGC-1α, resulting in the enhanced transcriptional activity of ERRγ.

Troglitazone

97322-87-7sc-200904
sc-200904B
sc-200904A
5 mg
10 mg
25 mg
$110.00
$204.00
$435.00
9
(1)

Troglitazone, a PPARγ agonist, stimulates PGC-1α activity which in turn enhances the transcriptional function of ERRγ.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$80.00
$220.00
$460.00
64
(2)

Although better known for its interaction with SIRT1 and other targets, it has shown potential ERRγ agonistic activity.

Dihydrocapsaicin

19408-84-5sc-202578
sc-202578A
10 mg
50 mg
$52.00
$156.00
1
(1)

Dihydrocapsaicin is an agonist of TRPV1, which enhances calcium influx and activates CAMKII. Activated CAMKII can phosphorylate PGC-1α, which enhances the transcriptional activity of ERRγ.

3-Chloroindazole

29110-74-5sc-231634
5 g
$78.00
(0)

A synthetic compound that has been reported to act as a selective agonist for ERRγ.