ENSMUSG00000074179 Inhibitors
Chemical inhibitors of ENSMUSG00000074179 utilize diverse molecular mechanisms to impede the protein's activity within cellular processes. Alizarin, for example, can directly bind to the protein's active site, which competes with its natural substrates. This competition effectively prevents the substrates from interacting with ENSMUSG00000074179 and carrying out its normal enzymatic functions. Similarly, Quercetin can inhibit the protein by stabilizing its inactive form, thus preventing the structural changes that are necessary for its activation. This stabilization not only inhibits ENSMUSG00000074179 itself but also can disrupt its interaction with other cellular molecules that are essential for its function.
Other inhibitors interfere with signaling pathways that are crucial for the protein's activity. Genistein, for instance, can inhibit ENSMUSG00000074179 by blocking the phosphorylation it requires for activation, acting as a tyrosine kinase inhibitor. PD 98059 and U0126 both target the MAP kinase pathway, with PD 98059 specifically inhibiting MEK, thereby preventing the activation of MAP kinase, and U0126 preventing necessary phosphorylation steps. LY294002 and Wortmannin exert their effects by inhibiting PI3K, an upstream regulator in pathways that involve ENSMUSG00000074179, leading to a reduction in the protein's signaling activities. SB203580 and SP600125 inhibit the p38 MAP kinase and JNK, respectively, each contributing to a decrease in ENSMUSG00000074179 activity by impeding different components of the MAP kinase signaling pathways. SB431542 selectively inhibits the TGF-β type I receptor ALK5, reducing signaling through pathways that involve ENSMUSG00000074179, while Gefitinib targets the EGFR, which is another significant player in the regulatory pathways of ENSMUSG00000074179. Each of these inhibitors, through their unique interactions with different molecules and pathways, can reduce the functional activity of ENSMUSG00000074179.
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Alizarin | 72-48-0 | sc-214519 sc-214519A | 1.5 g 100 g | $21.00 $51.00 | ||
Alizarin directly inhibits ENSMUSG00000074179 by binding to the active site where it competes with the natural substrates of the enzyme, preventing their interaction and subsequent catalytic activity. This inhibition process specifically disrupts the enzyme's ability to carry out its normal metabolic functions within the cell. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein inhibits ENSMUSG00000074179 by interfering with the phosphorylation process that the protein relies on for its activation. This compound acts as a tyrosine kinase inhibitor, and since phosphorylation is a common post-translational modification that can activate enzymes, its inhibition can result in decreased activity of ENSMUSG00000074179. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin inhibits ENSMUSG00000074179 by stabilizing the inactive form of the protein and preventing its conformational change required for activation. This binding also potentially disrupts the protein's interaction with other cellular molecules necessary for its function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD 98059 inhibits ENSMUSG00000074179 by blocking the MAP kinase pathway, which is a signaling pathway that the protein is part of. This chemical specifically inhibits MEK, which in turn prevents the activation of MAP kinase that could be downstream of ENSMUSG00000074179 activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 inhibits ENSMUSG00000074179 by acting as a PI3K inhibitor, which is an upstream regulator in pathways that ENSMUSG00000074179 is involved in. Inhibition of PI3K leads to a reduction in downstream signaling activities, which includes the functional processes of ENSMUSG00000074179. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 inhibits ENSMUSG00000074179 by impeding the p38 MAP kinase pathway. Since this signaling pathway has a role in the regulation of ENSMUSG00000074179, the inhibition of p38 MAP kinase directly reduces the functional activity of the protein. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 functions as an inhibitor of MEK, which is also part of the MAP kinase pathway that ENSMUSG00000074179 operates within. By inhibiting MEK, U0126 effectively reduces the protein's activity by preventing the necessary phosphorylation and activation steps. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin inhibits ENSMUSG00000074179 by irreversibly inhibiting PI3K. Given that PI3K is crucial for several cellular signaling pathways, the inhibition of PI3K by Wortmannin results in a decrease in the activity of ENSMUSG00000074179 as it interrupts the signaling cascades in which the protein is involved. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits ENSMUSG00000074179 by binding to FKBP12 and forming a complex that inhibits the mTOR pathway, which is a key regulator of cell growth and metabolism that the protein is associated with. The inhibition of mTOR leads to a reduction in the activity of downstream proteins including ENSMUSG00000074179. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 inhibits ENSMUSG00000074179 by acting as an inhibitor of JNK, another kinase within the MAP kinase signaling pathways. As JNK activity is reduced, the subsequent signaling events that lead to the activation of ENSMUSG00000074179 are also inhibited. | ||||||