ENSA Activators
ENSA Activators refer to a class of compounds that can indirectly or directly modulate the activity of the alpha-endosulfine (ENSA) protein. ENSA, being a member of a unique family of proteins, plays pivotal roles in cell cycle regulation and inhibits certain protein phosphatase activities. The modulation of its activity often hinges on its phosphorylation status, which, in many instances, is intertwined with the activity of AMP-activated protein kinase (AMPK). Therefore, compounds that influence AMPK activity can serve as indirect mediators of ENSA's function.
Compounds such as Metformin and 5-Aminoimidazole-4-carboxamide ribonucleotide (AICAR) are exemplars in this regard. Metformin acts by elevating the cellular AMP/ATP ratio, leading to AMPK activation. In contrast, AICAR transforms into ZMP within cells, an AMP analog, thereby activating AMPK by emulating the effects of AMP. Other chemicals like Berberine and Salicylate also elicit their effects through AMPK activation, with the former increasing the AMP/ATP ratio and the latter acting directly on AMPK. Similarly, Resveratrol indirectly stimulates AMPK via the activation of Sirtuin 1 (SIRT1). On the other hand, compounds like Dorsomorphin, though primarily AMPK inhibitors, can in certain conditions indirectly activate AMPK. Synthetic molecules like Thienopyridone bind directly to AMPK, facilitating its activation. These various modes of action, though diverse, converge on the common goal of modulating ENSA activity, making them significant players in the realm of ENSA activators.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR is taken up into cells and transformed into ZMP, an AMP analog. ZMP activates AMPK by mimicking the effects of AMP. This can indirectly affect ENSA activity via AMPK-mediated pathways. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine has been shown to activate AMPK via an increase in AMP/ATP ratio. The activated AMPK can subsequently play a role in modulating ENSA's phosphorylation status. | ||||||
Sodium Salicylate | 54-21-7 | sc-3520 sc-3520A sc-3520B sc-3520C | 1 g 25 g 500 g 1 kg | $10.00 $26.00 $82.00 $139.00 | 8 | |
Salicylate directly activates AMPK. By activating AMPK, it might indirectly modulate the phosphorylation and activity of ENSA. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is believed to activate AMPK indirectly through the activation of Sirtuin 1 (SIRT1). Active AMPK can then potentially influence ENSA. | ||||||
BML-275 | 866405-64-3 | sc-200689 sc-200689A | 5 mg 25 mg | $96.00 $355.00 | 69 | |
While primarily an AMPK inhibitor, in certain contexts or concentrations, Dorsomorphin might indirectly activate AMPK. This can have downstream effects, potentially including modulation of ENSA. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $184.00 $741.00 $1076.00 $3417.00 $5304.00 | 23 | |
This compound directly binds and activates AMPK, potentially affecting ENSA's phosphorylation and activity indirectly. | ||||||
Oridonin, R. rubescens | 28957-04-2 | sc-202751 | 5 mg | $77.00 | ||
Oridonin activates AMPK, possibly through the increased production of reactive oxygen species (ROS) or alterations in mitochondrial function. Activated AMPK can then have indirect effects on ENSA. | ||||||