ELOVL2 Activators
ELOVL2 activators would belong to a class of chemicals that modulate the elongation of very long-chain fatty acids by altering the biochemical pathways ELOVL2 is involved in or by affecting the substrate availability, enzyme stability, gene expression, or cellular localization. Such activators could act, for example, by increasing the levels of substrates that ELOVL2 uses for fatty acid elongation, such as malonyl-CoA or specific acyl-CoAs, through the manipulation of metabolic flux. They could also work by stabilizing ELOVL2 protein or increasing its gene expression via the modulation of transcription factors or epigenetic modifications that are known to affect ELOVL2.
Furthermore, these activators could influence membrane lipid composition, thus indirectly enhancing the activity of ELOVL2 by altering its lipid environment. Since ELOVL2 activity is crucial for the synthesis of long-chain polyunsaturated fatty acids, regulation of membrane fluidity and function could be a consequential mechanism of action. The exact chemical structure of such activators would be designed to interact with the regulatory components of the pathways governing these processes without affecting other similar enzymes or pathways to ensure specificity. The functional mechanisms of these compounds would be defined by their ability to enhance ELOVL2 activity, and this would be measurable in biochemical assays that assess the rate of fatty acid elongation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Palmitic Acid | 57-10-3 | sc-203175 sc-203175A | 25 g 100 g | $114.00 $286.00 | 2 | |
Palmitic acid, being a saturated long-chain fatty acid, is a substrate for ELOVL2. Its availability could enhance the function of ELOVL2 by providing more substrate for the elongation process, thereby increasing the production of very long-chain fatty acids (VLCFAs). | ||||||
α-Linolenic Acid | 463-40-1 | sc-205545 sc-205545A | 50 mg 250 mg | $38.00 $115.00 | 2 | |
Alpha-linolenic acid is an omega-3 fatty acid that serves as a substrate for elongation by enzymes like ELOVL2. Adequate levels of ALA can facilitate the activity of ELOVL2 in synthesizing longer-chain polyunsaturated fatty acids. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $41.00 | 9 | |
PPAR agonists such as Fenofibrate can modulate the expression of various genes including those involved in fatty acid metabolism. Although Fenofibrate is primarily known for its lipid-lowering effects, it could upregulate ELOVL2 expression indirectly. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a metabolite of vitamin A, can influence gene expression through its interaction with nuclear receptors. It could potentially enhance the transcription of genes including those coding for enzymes like ELOVL2. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels, which in turn can modulate gene expression. Elevated cAMP might lead to an upregulation of ELOVL2 expression indirectly by influencing transcription factors that control its gene expression. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $55.00 $125.00 | 13 | |
Pioglitazone is a PPAR-gamma agonist that influences lipid metabolism and could indirectly affect the activity of ELOVL2 by altering the expression of genes involved in fatty acid elongation and metabolism. | ||||||