ELAC2 Activators

ELAC2 activators are diverse in their chemical nature and underlying mechanisms of action. These activators work through various biochemical and cellular pathways, all of which ELAC2 is directly involved in. Dexamethasone and Rapamycin, for instance, enhance the functional activity of ELAC2 through the PI3K/AKT pathway. Tamoxifen, on the other hand, works by influencing the ER pathway, thereby enhancing the function of ELAC2.

On the other hand, Quercetin and Metformin activate the AMPK pathway, enhancing the function of ELAC2. Etoposide and Cisplatin, both known to induce DNA damage, stimulate the p53 pathway, where ELAC2 acts as a downstream effector, thus enhancing its functionality. Resveratrol, Curcumin, and Sulforaphane enhance ELAC2 activity through the SIRT1 and NRF2 pathways, respectively. Trolox, a vitamin E analogue, activates the antioxidant response element (ARE) pathway, enhancing the activity of ELAC2. Lastly, Phorbol 12-myristate 13-acetate (PMA), a PKC activator, influences the PKC pathway, leading to enhanced ELAC2 function.