eIF2S3 Activators
eIF2S3, as a core component of the eukaryotic initiation factor 2 complex, plays a crucial role in regulating the initiation phase of protein synthesis. Its activity largely pivots on the phosphorylation state of its partnering subunit, eIF2α. The ensemble of chemicals dubbed eIF2S3 Activators indirectly modulate the protein's activity through their interactions with various cellular pathways that influence eIF2α's phosphorylation. Notably, chemicals like Salubrinal and Sephin1, by inhibiting eIF2α dephosphorylation, can pave the way for increased eIF2S3 function.
In contrast, chemicals such as ISRIB, by enhancing eIF2B activity, counteract the inhibitory effects of eIF2α phosphorylation, thus indirectly facilitating eIF2S3's role in protein synthesis initiation. Moreover, ER stress inducers like Tunicamycin and Thapsigargin trigger pathways that influence eIF2 signaling, and by extension, eIF2S3's function.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Salubrinal | 405060-95-9 | sc-202332 sc-202332A | 1 mg 5 mg | $34.00 $104.00 | 87 | |
Inhibits dephosphorylation of eIF2α; can promote eIF2S3 function in the context of protein synthesis initiation. | ||||||
ISRIB | 1597403-47-8 | sc-488404 | 10 mg | $300.00 | 1 | |
Enhances eIF2B activity, counteracting eIF2α phosphorylation effects; can indirectly boost eIF2S3 function. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Induces ER stress and eIF2α phosphorylation; can affect eIF2S3 activity indirectly via the unfolded protein response. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
ER stress inducer, leading to eIF2α phosphorylation; can influence eIF2S3 activity within the protein synthesis machinery. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AMPK activator; through AMPK pathway, can indirectly affect eIF2S3-mediated protein synthesis initiation. | ||||||
Guanabenz acetate | 23256-50-0 | sc-203590 sc-203590A sc-203590B sc-203590C sc-203590D | 100 mg 500 mg 1 g 10 g 25 g | $102.00 $468.00 $832.00 $4162.00 $7283.00 | 2 | |
Enhances eIF2α phosphorylation via inhibiting its dephosphorylation; influences eIF2S3's role in translation initiation. | ||||||
Halofuginone | 55837-20-2 | sc-507290 | 100 mg | $1775.00 | ||
Activates amino acid starvation response, influencing eIF2 signaling; can indirectly impact eIF2S3. | ||||||