EGFL11 Activators
EGFL11 Activators, a diverse array of chemical compounds, play an instrumental role in modulating the activity of EGFL11 (EYS), a protein integral to ocular development and health. These activators primarily influence EGFL11's function through various biochemical pathways, contributing to its role in retinal cell proliferation, differentiation, and protection. Compounds like Retinoic Acid and Sodium Butyrate are key in this context, with the former modulating gene expression related to cell differentiation, thereby potentially enhancing EGFL11's involvement in ocular development. Sodium Butyrate, as a histone deacetylase inhibitor, impacts chromatin structure and gene expression, which could influence EGFL11's regulatory role in the retina.
Other notable compounds include Lithium Chloride, which inhibits GSK-3 and thereby may indirectly affect EGFL11 through the Wnt signaling pathway, crucial for retinal cell survival and proliferation. Forskolin and Dexamethasone offer additional regulatory pathways, with Forskolin increasing cAMP levels, influencing cellular signaling pathways relevant to eye development, and Dexamethasone modulating inflammatory pathways, potentially impacting EGFL11 in ocular repair processes. The role of Rapamycin and N-Acetylcysteine is crucial too, the former as an mTOR inhibitor affecting cell growth and autophagy, and the latter as an antioxidant protecting retinal cells from oxidative stress.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Influences gene expression related to cell differentiation; could enhance EGFL11's role in ocular development and function. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
A histone deacetylase inhibitor; potentially affects EGFL11 by altering chromatin structure and gene expression in the retina. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Inhibits GSK-3, impacting Wnt signaling; may indirectly affect EGFL11's role in retinal cell proliferation and survival. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Increases cAMP levels, potentially influencing EGFL11 in cellular signaling pathways relevant to eye development. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
A glucocorticoid that can influence inflammatory pathways; might impact EGFL11's function in ocular inflammation and repair. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
mTOR inhibitor; potentially affects EGFL11 by modulating cell growth and autophagy in retinal cells. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
An antioxidant that could influence EGFL11's role in protecting retinal cells from oxidative stress. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
A ROCK inhibitor, may enhance EGFL11's function in cytoskeletal remodeling crucial for retinal cell morphology and function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
MEK inhibitor, could indirectly affect EGFL11 by modulating the MAPK/ERK pathway in retinal cells. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
TGF-β receptor kinase inhibitor; might influence EGFL11's role in fibrosis and tissue remodeling in the eye. | ||||||