Date published: 2026-5-16

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EG667693 Activators

Spermatogenesis associated 31 subfamily E member 4 (SPATA31E4) activators include chemicals that enhance the processes surrounding spermatogenesis, a biological process to which SPATA31E4 is directly connected. Retinoic acid, by regulating gene expression specifically related to spermatogenesis, effectively enhances the functional activity of SPATA31E4. Testolactone and clomiphene citrate, through their actions on hormone levels, indirectly bolster the spermatogenic process that SPATA31E4 is a part of, leading to its functional enhancement.

Essential micronutrients like zinc and selenium, as well as vitamin compounds such as Vitamin E and Vitamin C, play supportive roles in testicular health and spermatogenesis, contributing to the indirect enhancement of SPATA31E4 activity. Hormonal compounds such as gonadorelin and HCG directly stimulate the release of gonadotropins or mimic LH activity, respectively, which supports the hormonal milieu conducive to spermatogenesis. This hormonal support is crucial for the functional upregulation of SPATA31E4. Additionally, precursors to critical molecules, such as DHEA for testosterone and L-Arginine for nitric oxide, provide foundational support for testicular function and spermatogenesis, which is expected to enhance the functional activity of SPATA31E4.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$66.00
$325.00
$587.00
$1018.00
28
(1)

Retinoic acid, a metabolite of vitamin A, is known to play a crucial role in spermatogenesis. It binds to retinoic acid receptors, which in turn can regulate gene expression. The activation of gene expression pathways by retinoic acid can enhance the functional activity of spermatogenesis associated 31 subfamily E member 4 (SPATA31E4) due to its involvement in spermatogenesis.

Zinc

7440-66-6sc-213177
100 g
$48.00
(0)

Zinc is essential for proper testicular development and function. Zinc sulfate supplementation can influence the hormonal milieu necessary for spermatogenesis, where SPATA31E4 is functionally active, thereby indirectly enhancing its activity.

Cholecalciferol

67-97-0sc-205630
sc-205630A
sc-205630B
1 g
5 g
10 g
$71.00
$163.00
$296.00
2
(1)

Vitamin D3 regulates calcium balance and affects testosterone levels. By influencing testosterone levels, it can indirectly enhance spermatogenesis and the functional activity of SPATA31E4.

β-Estradiol

50-28-2sc-204431
sc-204431A
500 mg
5 g
$63.00
$182.00
8
(1)

Estradiol, while primarily an estrogen, has complex effects on male reproduction, including a role in the regulation of spermatogenesis. By modulating the spermatogenic process, estradiol can indirectly affect the activity of SPATA31E4.

Spermidine

124-20-9sc-215900
sc-215900B
sc-215900A
1 g
25 g
5 g
$57.00
$607.00
$176.00
(2)

Spermidine is a polyamine that is involved in cellular metabolism and growth. It is known to support spermatogenesis, which could enhance the activity of SPATA31E4.

Selenium

7782-49-2sc-250973
50 g
$62.00
1
(1)

Selenium is a trace element that plays a critical role in spermatogenesis. Adequate selenium levels support testicular development and function, potentially enhancing the activity of SPATA31E4.

L-Carnitine

541-15-1sc-205727
sc-205727A
sc-205727B
sc-205727C
1 g
5 g
100 g
250 g
$23.00
$34.00
$79.00
$179.00
3
(1)

L-Carnitine is involved in mitochondrial fatty acid transport. It is also associated with male fertility and spermatogenesis, potentially enhancing the activity of SPATA31E4.

Coenzyme Q10

303-98-0sc-205262
sc-205262A
1 g
5 g
$71.00
$184.00
1
(1)

Coenzyme Q10 is involved in the electron transport chain and is an antioxidant. Its role in energy production and protection against oxidative stress can support spermatogenesis, potentially enhancing the activity of SPATA31E4.