EG666955 Inhibitors
The term Ston2 inhibitors refers to a diverse group of chemicals that indirectly influence the activity of the protein Ston2. Ston2's role predominantly lies in clathrin-mediated endocytosis and hematopoietic progenitor cell differentiation, processes critical for cellular function and development. Chemicals classified as Ston2 inhibitors achieve their effects not by binding directly to Ston2 but by targeting associated cellular mechanisms and proteins that are essential for the proper functioning of Ston2.
These inhibitors exert their influence through various modes of action, such as preventing the GTPase activity of dynamin, which is crucial for the scission of clathrin-coated vesicles during endocytosis. Others, like Pitstop 2, act by blocking the recruitment of clathrin to adaptor proteins, thereby potentially impairing the formation of vesicles that Ston2 would typically be involved in. Some inhibitors, such as Wortmannin and Tyrphostin AG1478, interfere with intracellular signaling pathways that are indirectly associated with Ston2's role in vesicle trafficking and cell differentiation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
Dynamin inhibitor that can prevent the scission of clathrin-coated vesicles from the plasma membrane, potentially affecting Ston2's role in vesicle formation. | ||||||
Pitstop 2 | 1419320-73-2 | sc-507418 | 10 mg | $360.00 | ||
Clathrin terminal domain inhibitor that can block the assembly of clathrin lattices, indirectly affecting Ston2 activity in clathrin-coated vesicle formation. | ||||||
Ikarugamycin | 36531-78-9 | sc-202179 | 500 µg | $189.00 | 4 | |
Clathrin-mediated endocytosis inhibitor that can disrupt the formation of clathrin-coated pits, thereby possibly affecting the function of Ston2 in vesicle assembly. | ||||||
Desipramine hydrochloride | 58-28-6 | sc-200158 sc-200158A | 100 mg 1 g | $66.00 $117.00 | 6 | |
Known to inhibit clathrin-dependent endocytosis by affecting the recruitment of adaptor proteins, potentially influencing Ston2's adaptor activity. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $61.00 $110.00 | 21 | |
Cationic amphiphilic drug that can inhibit clathrin-mediated endocytosis, potentially altering Ston2's role in vesicle formation. | ||||||
Tyrphostin A23 | 118409-57-7 | sc-3554 | 10 mg | $112.00 | 13 | |
Inhibitor of receptor-mediated endocytosis that can block the internalization of cell surface receptors, potentially affecting Ston2-related pathways. | ||||||
Dansylcadaverine | 10121-91-2 | sc-214851 sc-214851A sc-214851B | 100 mg 250 mg 1 g | $52.00 $89.00 $240.00 | 4 | |
Inhibitor of transglutaminase and endocytosis that may interfere with clathrin-coated vesicle formation and indirectly affect Ston2's function. | ||||||
Filipin III | 480-49-9 | sc-205323 sc-205323A | 500 µg 1 mg | $118.00 $148.00 | 26 | |
Polyene macrolide that can disrupt cholesterol and might alter the lipid composition of membranes, affecting clathrin-coated vesicle formation and potentially Ston2's function. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
Cyclin-dependent kinase inhibitor that may affect cell cycle-related endocytic pathways, potentially influencing Ston2's function during hematopoietic progenitor cell differentiation. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
PI3 kinase inhibitor that can affect various intracellular signaling pathways, including those involved in vesicle trafficking, potentially affecting Ston2's function in endocytosis. | ||||||