EG436188 Inhibitors
EG436188 inhibitors are a class of small molecules specifically designed to inhibit the activity of a certain protein or enzyme within biological systems, associated with the EG436188 chemical identifier. These inhibitors are characterized by their ability to bind to their target molecule with high specificity, often interacting through key binding sites that disrupt the protein's normal activity. Structurally, they are comprised of various organic frameworks, often incorporating heterocyclic rings, aromatic moieties, and functional groups like amides, sulfonamides, or halogens that enhance their affinity and specificity for their target. Such chemical features are designed to optimize interactions like hydrogen bonding, π-π stacking, and hydrophobic contacts, ensuring that these inhibitors have a strong binding capacity. The molecular design of EG436188 inhibitors allows for selective modulation of their biological targets, providing a tool to explore biochemical pathways and molecular mechanisms.
In terms of their chemical properties, EG436188 inhibitors often possess a balanced profile in terms of lipophilicity and hydrophilicity, facilitating adequate solubility and bioavailability within biological systems. This balance is crucial for ensuring the appropriate distribution and stability of the compound in various environments, allowing for optimal interaction with the target proteins. Their molecular weights typically range from low to moderate, which supports their ability to penetrate cells and reach intracellular targets. Additionally, their structures are often optimized to minimize off-target effects and enhance specificity. The design of these inhibitors relies on structure-activity relationship (SAR) studies, which help to refine their chemical structures for improved potency, selectivity, and pharmacokinetic properties. These properties collectively enable EG436188 inhibitors to serve as valuable biochemical tools in probing cellular pathways and understanding molecular interactions at a detailed level, providing insights into the molecular dynamics and regulatory mechanisms of their target proteins.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $180.00 $726.00 $1055.00 $3350.00 $5200.00 | 23 | |
AMP-activated protein kinase (AMPK) activator that indirectly inhibits Ssxb16. A-769662 activates AMPK, which negatively regulates mTORC1 via phosphorylation, leading to downstream effects on cell growth and protein synthesis, indirectly impacting Ssxb16. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Phosphatidylinositol 3-kinase (PI3K) inhibitor affecting the PI3K/AKT pathway. By inhibiting PI3K, Wortmannin disrupts AKT signaling, which plays a role in cell survival and proliferation, indirectly influencing Ssxb16 function through modulation of key cellular pathways. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
Bromodomain and extraterminal (BET) inhibitor targeting BRD4. JQ1 disrupts the interaction between BRD4 and acetylated histones, leading to downregulation of c-Myc and other genes. Indirectly, this alters cellular processes linked to Ssxb16 expression and function. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
Transforming growth factor-beta (TGF-β) receptor inhibitor impacting TGF-β signaling. By blocking TGF-β receptor, SB-431542 interferes with downstream pathways, potentially modulating cellular processes related to Ssxb16. This indirect inhibition may alter gene expression and function. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
c-Jun N-terminal kinase (JNK) inhibitor affecting the JNK signaling pathway. SP600125 disrupts JNK activation, influencing transcription factors like AP-1. This indirect impact on cellular signaling pathways may result in alterations in Ssxb16 expression and activity. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $66.00 $153.00 | 16 | |
Heat shock protein 90 (HSP90) inhibitor affecting protein folding. 17-AAG disrupts HSP90 function, leading to degradation of client proteins like AKT and ERBB2. This indirect influence on signaling pathways could impact the activity of Ssxb16 and related cellular functions. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
PI3K inhibitor targeting the PI3K/AKT pathway. LY294002 blocks PI3K, affecting downstream signaling and cellular processes linked to cell survival and growth. This indirect modulation may influence Ssxb16 function through alterations in key signaling cascades. | ||||||
Niclosamide | 50-65-7 | sc-250564 sc-250564A sc-250564B sc-250564C sc-250564D sc-250564E | 100 mg 1 g 10 g 100 g 1 kg 5 kg | $37.00 $77.00 $184.00 $510.00 $1224.00 $5814.00 | 8 | |
Wnt/β-catenin pathway inhibitor by targeting Dishevelled. Niclosamide interferes with Wnt signaling, impacting β-catenin stability and downstream transcription. This indirect inhibition may lead to changes in cellular processes related to Ssxb16 expression and function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
Mitogen-activated protein kinase kinase (MEK) inhibitor affecting the MAPK pathway. PD98059 disrupts MAPK signaling, potentially altering transcription factors and gene expression linked to Ssxb16. This indirect impact on cellular pathways may influence the function of Ssxb16. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $260.00 $925.00 | 5 | |
Histone acetyltransferase (HAT) inhibitor targeting p300/CBP. C646 disrupts acetylation of histones, affecting chromatin structure and gene expression. This indirect modulation may impact the transcriptional regulation of genes, including Ssxb16, and influence its function. | ||||||