EG368203 Activators
Brcc3dc, a crucial component of the BRCA1/BRCA2-containing complex, plays a pivotal role in cellular processes such as double-strand break repair and histone H2A K63-linked deubiquitination. Predicted to enable metallopeptidase activity, polyubiquitin modification-dependent protein binding, and thiol-dependent deubiquitinase, Brcc3dc operates upstream of or within proteolysis and is part of both the BRCA1-A and BRISC complexes. The multifaceted functions of Brcc3dc highlight its significance in maintaining genomic stability and regulating cellular responses to DNA damage.
Activation of Brcc3dc involves intricate regulatory mechanisms orchestrated by specific chemicals. N-Ethylmaleimide stimulates Brcc3dc by inhibiting thiol-dependent deubiquitinases, enhancing polyubiquitin modification-dependent protein binding, and promoting histone H2A K63-linked deubiquitination. ML323 indirectly up-regulates Brcc3dc by stabilizing the BRISC complex components, enhancing metallopeptidase activity and promoting its role in double-strand break repair. IU1-47 and WP1130 activate Brcc3dc by inhibiting deubiquitinases, leading to increased polyubiquitin modification-dependent protein binding activity and enhanced involvement in histone H2A K63-linked deubiquitination. The diverse range of chemicals influencing Brcc3dc reveals its tight regulation and integration into cellular processes crucial for genome integrity. Understanding the detailed mechanisms of Brcc3dc activation provides insights into potential strategies for modulating its functions in the context of DNA repair and ubiquitin-dependent pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
N-Ethylmaleimide | 128-53-0 | sc-202719A sc-202719 sc-202719B sc-202719C sc-202719D | 1 g 5 g 25 g 100 g 250 g | $22.00 $69.00 $214.00 $796.00 $1918.00 | 19 | |
N-Ethylmaleimide activates Brcc3dc by inhibiting thiol-dependent deubiquitinases, leading to enhanced polyubiquitin modification-dependent protein binding activity and increased involvement in histone H2A K63-linked deubiquitination. | ||||||
IU1 | 314245-33-5 | sc-361215 sc-361215A sc-361215B | 10 mg 50 mg 100 mg | $138.00 $607.00 $866.00 | 2 | |
IU1-47 stimulates Brcc3dc by inhibiting ubiquitin-specific proteases, enhancing polyubiquitin modification-dependent protein binding activity, and promoting its involvement in histone H2A K63-linked deubiquitination. | ||||||
WP1130 | 856243-80-6 | sc-364650 sc-364650A | 10 mg 50 mg | $490.00 $1484.00 | 1 | |
WP1130 up-regulates Brcc3dc by inhibiting deubiquitinases, leading to increased polyubiquitin modification-dependent protein binding activity and enhanced involvement in histone H2A K63-linked deubiquitination. | ||||||
P22077 | 1247819-59-5 | sc-478536 | 10 mg | $165.00 | ||
P22077 activates Brcc3dc by inhibiting deubiquitinases, promoting thiol-dependent deubiquitinase activity and enhancing its role in double-strand break repair. | ||||||
PR 619 | 2645-32-1 | sc-476324 sc-476324A sc-476324B | 1 mg 5 mg 25 mg | $77.00 $188.00 $431.00 | 1 | |
PR-619 stimulates Brcc3dc by inhibiting deubiquitinases, enhancing polyubiquitin modification-dependent protein binding activity, and promoting its involvement in histone H2A K63-linked deubiquitination. | ||||||
Spautin-1 | 1262888-28-7 | sc-507306 | 10 mg | $168.00 | ||
Spautin-1 up-regulates Brcc3dc by inhibiting deubiquitinases, leading to increased polyubiquitin modification-dependent protein binding activity and enhanced involvement in histone H2A K63-linked deubiquitination. | ||||||
UCH-L1 Inhibitor Inhibitor | 668467-91-2 | sc-356182 | 10 mg | $204.00 | 1 | |
UCH-L1 Inhibitor indirectly up-regulates Brcc3dc by inhibiting the proteasome, leading to stabilization of BRISC complex components, enhancing metallopeptidase activity and promoting its role in double-strand break repair. | ||||||